<p>The North-Eastern Europe and Northern Asia open-access dataset (NEENA) is a compilation of over 18,700 isotopic measurements (δ¹³C, δ¹⁵N, δ³⁴S, δ¹⁸O, ⁸⁷Sr/⁸⁶Sr), predominantly from archaeological human, animal, and plant samples originating from more than 750 sites ranging geographically from the Baltic and Eastern Europe to North-Central Asia and dating between 70,000 years BP and modern times. For each isotope record included in the dataset, information relating to the taxonomic categorisation of the sampled material (e.g., animal and plant species or genus names), the sample type (e.g., bone, dentine, enamel) and contextual, chronological, provenance (i.e., site location and country), and laboratory details are provided where available from original publications. The NEENA dataset can be used to conduct comparative studies of palaeodiet, spatial mobility, paleo-environmental conditions, organic remains preservation, and radiocarbon reservoir effects. NEENA is available in an open-access format via the Pandora data platform.</p>