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<p><i>Phlomoides rotata</i> (Duyiwei), a threatened Tibetan medicinal plant with anti-inflammatory and analgesic properties, has an understudied genome. We generated a chromosome-level assembly of its 4.12 Gb genome using Oxford Nanopore, PacBio HiFi, Illumina, and Hi-C sequencing, anchoring 22 pseudochromosomes (contig N50 = 173.16 Mb, scaffold N50 = 191.90 Mb). Annotation identified 70,881 protein-coding genes (99.3% complete via BUSCO). Comparative genomic analyses provide insights into the phylogenetic relationships of <i>P. rotata</i>. These data provide insights into high-altitude adaptation, bioactive compound biosynthesis, and evolutionary history, supporting conservation and drug development efforts.</p>

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Chromosome-level Genome Assembly of the Tibetan Medicinal Plant Duyiwei (Phlomoides rotata)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Zhongqiong Tian,
  • Junwei Wang,
  • Zhefei Zeng,
  • Jinfang Chen,
  • Ticao Zhang,
  • Qiong La

摘要

Phlomoides rotata (Duyiwei), a threatened Tibetan medicinal plant with anti-inflammatory and analgesic properties, has an understudied genome. We generated a chromosome-level assembly of its 4.12 Gb genome using Oxford Nanopore, PacBio HiFi, Illumina, and Hi-C sequencing, anchoring 22 pseudochromosomes (contig N50 = 173.16 Mb, scaffold N50 = 191.90 Mb). Annotation identified 70,881 protein-coding genes (99.3% complete via BUSCO). Comparative genomic analyses provide insights into the phylogenetic relationships of P. rotata. These data provide insights into high-altitude adaptation, bioactive compound biosynthesis, and evolutionary history, supporting conservation and drug development efforts.