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<p><i>Anopheles</i> mosquitoes are known as dominant vectors of malaria parasites and other viral and bacterial pathogens. Deciphering <i>Anopheles</i> genomes has opened a new era of research and allowed in-depth investigation of several molecular mechanisms involved in pathogen transmission. However, there is a lack of appropriate model systems to study specific vector-pathogen interactions at the molecular level. Even inbred mosquito colonies represent genetically heterogeneous population and require special care facilities. Insect cell cultures could serve as a useful alternative due to the ease of handling and maintenance, especially for genomic studies requiring millions of cells per experiment. Here, we provide chromatin contact maps and a dataset of epigenetic characteristics, including histone mark profiles and RNA-seq data, as well as transfection conditions and promoter specificity for the mosquito cell line MSQ43.</p>

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Chromatin landscape, transcriptomic and ChIP-seq profiling of Anopheles stephensi MSQ43 cell line

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月26日

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  • Varvara Lukyanchikova,
  • Miroslav Nuriddinov,
  • Anna Khabarova,
  • Maria Gridina,
  • Andrey Popov,
  • Polina Belokopytova,
  • Igor V. Sharakhov,
  • Veniamin Fishman

摘要

Anopheles mosquitoes are known as dominant vectors of malaria parasites and other viral and bacterial pathogens. Deciphering Anopheles genomes has opened a new era of research and allowed in-depth investigation of several molecular mechanisms involved in pathogen transmission. However, there is a lack of appropriate model systems to study specific vector-pathogen interactions at the molecular level. Even inbred mosquito colonies represent genetically heterogeneous population and require special care facilities. Insect cell cultures could serve as a useful alternative due to the ease of handling and maintenance, especially for genomic studies requiring millions of cells per experiment. Here, we provide chromatin contact maps and a dataset of epigenetic characteristics, including histone mark profiles and RNA-seq data, as well as transfection conditions and promoter specificity for the mosquito cell line MSQ43.