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<p>The T-cell receptor (TCR) repertoire, unique to each individual, forms a critical component of the adaptive immune system and serves as a defense mechanism against diverse pathogens. This repertoire encompasses a vast diversity of sequences, which can be profiled through high-throughput sequencing technologies. In this study, we present and provide a dataset of TCR sequencing data derived from 215 blood samples collected from newly diagnosed colorectal cancer (CRC) patients prior to any surgical or systemic treatment. Patients were classified according to the TNM staging system, enabling the inclusion of stage and risk labels specific to CRC. Dynamic changes in the TCR repertoire, such as the expansion or contraction of specific clonotypes, are known to reflect immune responses to disease and therapeutic interventions. This dataset provides a comprehensive snapshot of the pre-treatment TCR repertoire in CRC, offering valuable insights into immune system behavior in the context of cancer. The data can serve as a resource for further research into CRC immunology, biomarker discovery, and risk assessment studies.</p>

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A Large-Scale Dataset of Pre-Treatment TCR Repertoires in Colorectal Cancer Patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月29日

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  • Romi Goldner Kabeli,
  • Ben Boursi,
  • Or Malca,
  • Alona Zilberberg,
  • Sol Efroni

摘要

The T-cell receptor (TCR) repertoire, unique to each individual, forms a critical component of the adaptive immune system and serves as a defense mechanism against diverse pathogens. This repertoire encompasses a vast diversity of sequences, which can be profiled through high-throughput sequencing technologies. In this study, we present and provide a dataset of TCR sequencing data derived from 215 blood samples collected from newly diagnosed colorectal cancer (CRC) patients prior to any surgical or systemic treatment. Patients were classified according to the TNM staging system, enabling the inclusion of stage and risk labels specific to CRC. Dynamic changes in the TCR repertoire, such as the expansion or contraction of specific clonotypes, are known to reflect immune responses to disease and therapeutic interventions. This dataset provides a comprehensive snapshot of the pre-treatment TCR repertoire in CRC, offering valuable insights into immune system behavior in the context of cancer. The data can serve as a resource for further research into CRC immunology, biomarker discovery, and risk assessment studies.