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<p>Nguni sheep (<i>Ovis aries</i>) are indigenous to the Southern Africa region and common within the smallholder and poor resources farming systems. They are well adapted to different agroecological regions. However, limited genomic resources such as high-quality reference genomes have hindered our understanding of its adaptation and establishment of an effective breeding program. To address this, we assembled a chromosomal-level genome of Nguni sheep using a combination of PacBio HiFi reads and Omni-C reads. The genome size was estimated to be 2.9 Gb with a contig/scaffold N50 74 Mb and 99.6 Mb and a genome completeness of 96.1%, as estimated by the Benchmarking Universal Single-Copy Orthologs (BUSCO) program. The final genome encompassed a total of 25,926 protein-coding genes. The findings of this study provide a valuable genomic resource for understanding the adaptability of the Nguni sheep and the establishment of effective breeding programs.</p>

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A chromosomal level genome assembly of Nguni Sheep, Ovis aries

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月10日

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  • Lucky Tendani Nesengani,
  • Thendo Tshilate,
  • Sinebongo Mdyogolo,
  • Rae Smith,
  • Tracy Masebe,
  • Thomas Raphulu,
  • Acclaim Moila,
  • Abdoallah Sharaf,
  • Sadik Muzemil,
  • Isidore Houaga,
  • Anne Muigai,
  • A. Djikeng,
  • Josiah Kuja,
  • Sally Katee,
  • Julian O. Osuji,
  • Zahra Mungloo-Dilmohamud,
  • Marietjie Botes,
  • Skhumbuzo Mbizeni,
  • Erich Jarvis,
  • ThankGod Echezona Ebenezer,
  • Mapholi Ntanganedzeni

摘要

Nguni sheep (Ovis aries) are indigenous to the Southern Africa region and common within the smallholder and poor resources farming systems. They are well adapted to different agroecological regions. However, limited genomic resources such as high-quality reference genomes have hindered our understanding of its adaptation and establishment of an effective breeding program. To address this, we assembled a chromosomal-level genome of Nguni sheep using a combination of PacBio HiFi reads and Omni-C reads. The genome size was estimated to be 2.9 Gb with a contig/scaffold N50 74 Mb and 99.6 Mb and a genome completeness of 96.1%, as estimated by the Benchmarking Universal Single-Copy Orthologs (BUSCO) program. The final genome encompassed a total of 25,926 protein-coding genes. The findings of this study provide a valuable genomic resource for understanding the adaptability of the Nguni sheep and the establishment of effective breeding programs.