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<p>The Dallas Lifespan Brain Study (DLBS) was designed to integrate brain and cognition across the adult lifespan. Participants (n = 464) were between age 21 and 89 years at time of first assessment and returned approximately every 3.5–5 years for a second (n = 338) and third epoch (n = 224) of data collection. The three epochs included a comprehensive neuropsychological battery, questionnaires that assessed physical health, psychosocial status, and brain health, structural MRI scans (including T1-weighted imaging and diffusion-weighted imaging), a hypercapnia scan, an arterial spin labeling scan, and four functional fMRI scans. Additionally, measures of amyloid and tau were collected with AV-45 (Florbetapir) and AV-1451 (Flortaucipir). Key innovations were robust sampling of middle-aged participants and inclusion of PET data for amyloid and tau in a cognitively normal sample. This large data set has recently been published on OpenNeuro.org open-access and provides the opportunity for researchers to test many hypotheses about brain and cognition across human adulthood, including longitudinal hypotheses, with these data across a multi-year span.</p>

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The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月26日

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  • Denise C. Park,
  • Joseph P. Hennessee,
  • Evan T. Smith,
  • Micaela Y. Chan,
  • Xi Chen,
  • Marianna Dakanali,
  • Michelle E. Farrell,
  • Peiying Liu,
  • Hanzhang Lu,
  • Neil Rofsky,
  • Xiankai Sun,
  • Carol Tamminga,
  • William Moore,
  • Kristen M. Kennedy,
  • Karen Rodrigue,
  • Gagan S. Wig

摘要

The Dallas Lifespan Brain Study (DLBS) was designed to integrate brain and cognition across the adult lifespan. Participants (n = 464) were between age 21 and 89 years at time of first assessment and returned approximately every 3.5–5 years for a second (n = 338) and third epoch (n = 224) of data collection. The three epochs included a comprehensive neuropsychological battery, questionnaires that assessed physical health, psychosocial status, and brain health, structural MRI scans (including T1-weighted imaging and diffusion-weighted imaging), a hypercapnia scan, an arterial spin labeling scan, and four functional fMRI scans. Additionally, measures of amyloid and tau were collected with AV-45 (Florbetapir) and AV-1451 (Flortaucipir). Key innovations were robust sampling of middle-aged participants and inclusion of PET data for amyloid and tau in a cognitively normal sample. This large data set has recently been published on OpenNeuro.org open-access and provides the opportunity for researchers to test many hypotheses about brain and cognition across human adulthood, including longitudinal hypotheses, with these data across a multi-year span.