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<p>Accurate prediction of protein structures is essential for understanding biological functions and guiding biomedical research. However, maintaining synchronization between structure models and rapidly expanding, continuously evolving protein sequence databases remains a major challenge. Here, we present AlphaSync (<a href="https://alphasync.stjude.org/">alphasync.stjude.org</a>), a comprehensive resource that complements the AlphaFold Protein Structure Database. AlphaSync currently provides 2.6 million UniProt-synchronized structural models, including predictions for 40,016 updated proteins and isoforms from 925 species. AlphaSync achieves complete, up-to-date proteome coverage for 42 species, including humans, key pathogens and model organisms. It also provides residue-level annotations such as solvent accessibility, dihedral angles, intrinsic disorder status and over 4.7 billion atom-level noncovalent contacts. Its up-to-date structural models and detailed annotations will facilitate the study of protein structure–function relationships, assessment of sequence variants and machine learning tasks including protein design. With an intuitive web interface and application programming interface, AlphaSync enables protein research at scale and in detail.</p>

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AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt

  • 期刊论文

  • 发表日期：

    2025年11月11日

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  • Benjamin Lang,
  • Bálint Mészáros,
  • Besian I. Sejdiu,
  • Jaimin Patel,
  • M. Madan Babu

摘要

Accurate prediction of protein structures is essential for understanding biological functions and guiding biomedical research. However, maintaining synchronization between structure models and rapidly expanding, continuously evolving protein sequence databases remains a major challenge. Here, we present AlphaSync (alphasync.stjude.org), a comprehensive resource that complements the AlphaFold Protein Structure Database. AlphaSync currently provides 2.6 million UniProt-synchronized structural models, including predictions for 40,016 updated proteins and isoforms from 925 species. AlphaSync achieves complete, up-to-date proteome coverage for 42 species, including humans, key pathogens and model organisms. It also provides residue-level annotations such as solvent accessibility, dihedral angles, intrinsic disorder status and over 4.7 billion atom-level noncovalent contacts. Its up-to-date structural models and detailed annotations will facilitate the study of protein structure–function relationships, assessment of sequence variants and machine learning tasks including protein design. With an intuitive web interface and application programming interface, AlphaSync enables protein research at scale and in detail.