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<p>The choroid plexus (ChP), located in the brain ventricles, is largely composed of ChP epithelial cells that produce the cerebrospinal fluid (CSF) and form the blood–CSF barrier. At the ChP–brain attachment sites, we have discovered unique fibroblasts referred to as ChP base barrier cells (BBCs). We show that ChP BBCs originate from meningeal mesenchymal precursors, arrive early during development, remain throughout life and are conserved across species. ChP BBCs are transcriptionally similar to meningeal arachnoid barrier cells and are interconnected by both adherens and tight junctions. Notably, we provide evidence that the BBCs function as a barrier, controlling communication between the periphery and central nervous system. Moreover, during inflammatory insult, we observed a loss of barrier integrity and immune cell crossing. Altogether, our research revealed a barrier at the ChP base, crucial in protecting the central nervous system by compartmentalizing the ChP stroma, brain parenchyma and CSF.</p>

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Base barrier cells provide compartmentalization of choroid plexus, brain and CSF

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Daan Verhaege,
  • Clint De Nolf,
  • Lore Van Acker,
  • Wouter Claeys,
  • Jonas Castelein,
  • Elien Van Wonterghem,
  • Griet Van Imschoot,
  • Pieter Dujardin,
  • Ward De Spiegelaere,
  • Esther Hoste,
  • Fleur Boone,
  • Hart G. W. Lidov,
  • Neil Dani,
  • Julia Derk,
  • Anna Kremer,
  • Evelien Van Hamme,
  • Peter Borghgraef,
  • Saskia Lippens,
  • Maria K. Lehtinen,
  • Julie Siegenthaler,
  • Lien Van Hoecke,
  • Roosmarijn E. Vandenbroucke

摘要

The choroid plexus (ChP), located in the brain ventricles, is largely composed of ChP epithelial cells that produce the cerebrospinal fluid (CSF) and form the blood–CSF barrier. At the ChP–brain attachment sites, we have discovered unique fibroblasts referred to as ChP base barrier cells (BBCs). We show that ChP BBCs originate from meningeal mesenchymal precursors, arrive early during development, remain throughout life and are conserved across species. ChP BBCs are transcriptionally similar to meningeal arachnoid barrier cells and are interconnected by both adherens and tight junctions. Notably, we provide evidence that the BBCs function as a barrier, controlling communication between the periphery and central nervous system. Moreover, during inflammatory insult, we observed a loss of barrier integrity and immune cell crossing. Altogether, our research revealed a barrier at the ChP base, crucial in protecting the central nervous system by compartmentalizing the ChP stroma, brain parenchyma and CSF.