Scholarlink

<p>The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Axon initial segment dynamics during associative fear learning

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月23日

查看全文
  • Chloé Maëlle Benoit,
  • Dan Alin Ganea,
  • Ricardo Paricio-Montesinos,
  • Julia Esser,
  • Christian Thome,
  • Jan Maximilian Janssen,
  • Andrea Sattin,
  • Sabrina Milena Innocenti,
  • Sabine Krabbe,
  • Andreas Lüthi,
  • Tommaso Fellin,
  • Maren Engelhardt,
  • Jan Gründemann

摘要

The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.