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<p>Hesitation—that is, pausing an action in the face of uncertainty—is ubiquitous in daily life, yet little is known about its underlying neural circuitry. We present a new experimental paradigm that reliably evokes hesitation in mice and find that hesitation is mediated by indirect, but not direct, pathway neurons in the dorsomedial striatum. These data establish a new role for the indirect pathway in suppressing action under uncertainty.</p>

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The striatal indirect pathway mediates hesitation

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Matthew A. Geramita,
  • Susanne E. Ahmari,
  • Eric A. Yttri

摘要

Hesitation—that is, pausing an action in the face of uncertainty—is ubiquitous in daily life, yet little is known about its underlying neural circuitry. We present a new experimental paradigm that reliably evokes hesitation in mice and find that hesitation is mediated by indirect, but not direct, pathway neurons in the dorsomedial striatum. These data establish a new role for the indirect pathway in suppressing action under uncertainty.