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<p>In the neurodegenerative disease progressive supranuclear palsy (PSP), tau pathology progresses through the brain in a stereotypical spatiotemporal pattern, and where tau pathology appears, synapses are lost. We tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from presynapses to postsynapses. Using postmortem PSP brain samples and a living human brain slice culture model, we observe pathological tau in synaptic pairs and evidence that oligomeric tau can enter live human postsynapses. Proteomics revealed increased clusterin in synapses in PSP, and super-resolution imaging showed clusterin colocalized with tau in synapses in close enough proximity to be binding partners, which may mediate tau spread. Accumulation of tau in synapses correlated with synapse loss, and synaptic engulfment by astrocytes was observed, suggesting that astrocytes contribute to synapse loss. Together, these data indicate that targeting synaptic tau is a promising approach to treat PSP.</p>

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Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月16日

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  • Robert I. McGeachan,
  • Lois Keavey,
  • Elizabeth M. Simzer,
  • Ya Yin Chang,
  • Jamie L. Rose,
  • Maxwell P. Spires-Jones,
  • Mollie Gilmore,
  • Kristjan Holt,
  • Soraya Meftah,
  • Natalia Ravingerova,
  • Cristina Scutariu,
  • Lewis W. Taylor,
  • Declan King,
  • Makis Tzioras,
  • Jane Tulloch,
  • Sam A. Booker,
  • Imran Liaquat,
  • Nicole Hindley-Pollock,
  • Bethany Geary,
  • Colin Smith,
  • Paul M. Brennan,
  • Claire S. Durrant,
  • Tara L. Spires-Jones

摘要

In the neurodegenerative disease progressive supranuclear palsy (PSP), tau pathology progresses through the brain in a stereotypical spatiotemporal pattern, and where tau pathology appears, synapses are lost. We tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from presynapses to postsynapses. Using postmortem PSP brain samples and a living human brain slice culture model, we observe pathological tau in synaptic pairs and evidence that oligomeric tau can enter live human postsynapses. Proteomics revealed increased clusterin in synapses in PSP, and super-resolution imaging showed clusterin colocalized with tau in synapses in close enough proximity to be binding partners, which may mediate tau spread. Accumulation of tau in synapses correlated with synapse loss, and synaptic engulfment by astrocytes was observed, suggesting that astrocytes contribute to synapse loss. Together, these data indicate that targeting synaptic tau is a promising approach to treat PSP.