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<p>Optical tweezers are widely used in single-molecule biophysics, cell biomechanics and soft matter physics, but require a human operator, limiting throughput and repeatability. Here we present a smart optical tweezers platform, named SmartTrap, capable of performing complex experiments autonomously by integrating real-time three-dimensional particle tracking, custom electronics and a microfluidics system. Through a series of experiments, we demonstrate it can operate continuously, acquiring high-precision data over extended periods of time. By bridging the gap between manual experimentation and autonomous operation, SmartTrap establishes a robust and open-source framework for the next generation of optical tweezers research, capable of performing large-scale studies in single-molecule biophysics, cell mechanics and colloidal science with minimal experimental overhead and operator bias.</p>

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SmartTrap: automated precision experiments with optical tweezers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Martin Selin,
  • Antonio Ciarlo,
  • Giuseppe Pesce,
  • Lars Bengtsson,
  • Joan Camunas-Soler,
  • Vinoth Sundar Rajan,
  • Fredrik Westerlund,
  • L. Marcus Wilhelmsson,
  • Isabel Pastor,
  • Felix Ritort,
  • Steven B. Smith,
  • Carlos Bustamante,
  • Giovanni Volpe

摘要

Optical tweezers are widely used in single-molecule biophysics, cell biomechanics and soft matter physics, but require a human operator, limiting throughput and repeatability. Here we present a smart optical tweezers platform, named SmartTrap, capable of performing complex experiments autonomously by integrating real-time three-dimensional particle tracking, custom electronics and a microfluidics system. Through a series of experiments, we demonstrate it can operate continuously, acquiring high-precision data over extended periods of time. By bridging the gap between manual experimentation and autonomous operation, SmartTrap establishes a robust and open-source framework for the next generation of optical tweezers research, capable of performing large-scale studies in single-molecule biophysics, cell mechanics and colloidal science with minimal experimental overhead and operator bias.