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<p>RNA molecules interact extensively with each other and with RNA-binding proteins (RBPs) to regulate gene expression. To improve detection of RBP–RNA and RNA–RNA interactions, we developed the rbsSeeker and rriScan tools and integrated the interactions into the Encyclopedia of RNA Interactomes (ENCORI), providing web-based modules to explore RNA interactions. Using this resource, we identified and validated novel <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A)-associated proteins, an orphan small nucleolar RNA guiding rRNA pseudouridines and target-directed microRNA degradation events, establishing ENCORI as a framework for studying RNA interactomes.</p>

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An encyclopedic regulatory and functional atlas of RNA interactomes

  • 期刊论文

  • 发表日期：

    2026年5月25日

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  • Keren Zhou,
  • Junhong Huang,
  • Shurong Liu,
  • Wujian Zheng,
  • Shun Liu,
  • Yinghao Xing,
  • Yinan Cao,
  • Yibo Chen,
  • Xinping Hu,
  • Li Cai,
  • Jie Zhou,
  • Penghui Lin,
  • Jiajia Xuan,
  • Fangzhou Xie,
  • Lahong Xu,
  • Junhao Li,
  • Lingling Zheng,
  • Lianghu Qu,
  • Jianjun Chen,
  • Bin Li,
  • Jianhua Yang

摘要

RNA molecules interact extensively with each other and with RNA-binding proteins (RBPs) to regulate gene expression. To improve detection of RBP–RNA and RNA–RNA interactions, we developed the rbsSeeker and rriScan tools and integrated the interactions into the Encyclopedia of RNA Interactomes (ENCORI), providing web-based modules to explore RNA interactions. Using this resource, we identified and validated novel N6-methyladenosine (m6A)-associated proteins, an orphan small nucleolar RNA guiding rRNA pseudouridines and target-directed microRNA degradation events, establishing ENCORI as a framework for studying RNA interactomes.