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<p>Obesity and related conditions are associated with distressing food preoccupation that often culminates in dysregulated eating behaviors. Incretin-based therapies can reduce excessive weight in obesity, but their impact on dysregulated eating behaviors remains largely unexamined. Understanding how these pharmacologics engage the brain’s mesolimbic circuitry may inform the expansion of their therapeutic potential. We report a rare, first-in-human exploration of the physiological action of these therapies by examining the electrophysiology directly within the human nucleus accumbens. After a short-term course of tirzepatide, the patient-participant exhibited increased severe food preoccupation episodes, which were preceded by an increased delta–theta frequency (≤7 Hz) power in the nucleus accumbens region. We propose that the effects of an incretin-based therapy (tirzepatide) on food preoccupation may be associated with modulation of aberrant activity within this key hub of human mesolimbic circuitry.</p>

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Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月17日

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  • Wonkyung Choi,
  • Young-Hoon Nho,
  • Liming Qiu,
  • Andrew Chang,
  • Gustavo Campos,
  • Robert L. Seilheimer,
  • W. Bryan Wilent,
  • David Bakalov,
  • Nida Firdous,
  • Marie Kerr,
  • Disha Joshi,
  • Gabriella Maze,
  • Uros Topalovic,
  • Daniel Batista,
  • Nanthia Suthana,
  • Anastassia Amaro,
  • Matthew R. Hayes,
  • Iahn Cajigas,
  • Mario Cristancho,
  • Kelly C. Allison,
  • Bijan Pesaran,
  • Katherine W. Scangos,
  • Joshua I. Gold,
  • Thomas A. Wadden,
  • Casey H. Halpern

摘要

Obesity and related conditions are associated with distressing food preoccupation that often culminates in dysregulated eating behaviors. Incretin-based therapies can reduce excessive weight in obesity, but their impact on dysregulated eating behaviors remains largely unexamined. Understanding how these pharmacologics engage the brain’s mesolimbic circuitry may inform the expansion of their therapeutic potential. We report a rare, first-in-human exploration of the physiological action of these therapies by examining the electrophysiology directly within the human nucleus accumbens. After a short-term course of tirzepatide, the patient-participant exhibited increased severe food preoccupation episodes, which were preceded by an increased delta–theta frequency (≤7 Hz) power in the nucleus accumbens region. We propose that the effects of an incretin-based therapy (tirzepatide) on food preoccupation may be associated with modulation of aberrant activity within this key hub of human mesolimbic circuitry.