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<p>Existing evaluations of the National Health Service Diabetes Prevention Programme (NHS DPP) in England have demonstrated associated reductions in body weight, hemoglobin A1c and incident type 2 diabetes (T2D). In this study, we examined associations between completion of the NHS DPP and incidence of T2D and 30 other long-term conditions (LTCs), including LTCs considered linked to the programʼs interventional goals of body weight reduction, increased physical activity and improved diet quality (LTC-L) and LTCs considered to be possibly linked to those goals (LTC-PL). We found that completers of the NHS DPP had lower incidences of T2D, LTC-L and LTC-PL compared to non-attenders. Although these associations attenuated over time, they remained significant for all outcomes at 24 months with an odds ratio of 0.53 (95% confidence interval: 0.48–0.59) for T2D and rate ratios of 0.79 (0.74–0.84) and 0.80 (0.74–0.88) for LTC-L and LTC-PL, respectively. However, we were not able to directly conclude whether lower incidence rates were a direct result of completing the NHS DPP or due to residual bias stemming from unmeasured confounding and imprecision in the estimation of diagnosis.</p>

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Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月10日

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  • Emma Barron,
  • Paul Chappell,
  • Izzy Hatfield,
  • David C. D. Hope,
  • Xiaochen Ge,
  • Chirag Bakhai,
  • Dominique Bradley,
  • Ellie Bragan Turner,
  • Rupert Dunbar-Rees,
  • Nasrin Hafezparast,
  • Desmond G. Johnston,
  • Gary Wainman,
  • Adrian Pratt,
  • Eirion T. Slade,
  • Edward W. Gregg,
  • Kamlesh Khunti,
  • Jonathan Valabhji

摘要

Existing evaluations of the National Health Service Diabetes Prevention Programme (NHS DPP) in England have demonstrated associated reductions in body weight, hemoglobin A1c and incident type 2 diabetes (T2D). In this study, we examined associations between completion of the NHS DPP and incidence of T2D and 30 other long-term conditions (LTCs), including LTCs considered linked to the programʼs interventional goals of body weight reduction, increased physical activity and improved diet quality (LTC-L) and LTCs considered to be possibly linked to those goals (LTC-PL). We found that completers of the NHS DPP had lower incidences of T2D, LTC-L and LTC-PL compared to non-attenders. Although these associations attenuated over time, they remained significant for all outcomes at 24 months with an odds ratio of 0.53 (95% confidence interval: 0.48–0.59) for T2D and rate ratios of 0.79 (0.74–0.84) and 0.80 (0.74–0.88) for LTC-L and LTC-PL, respectively. However, we were not able to directly conclude whether lower incidence rates were a direct result of completing the NHS DPP or due to residual bias stemming from unmeasured confounding and imprecision in the estimation of diagnosis.