Scholarlink

<p><i>Streptococcus pyogenes</i> leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to <i>S. pyogenes</i> hinders vaccine development. Here we describe the evolution of serological profiles to conserved vaccine antigens and serotype-specific M proteins from birth and throughout the life course in The Gambia. As placentally transferred IgG waned after birth, serological evidence of new exposure was seen in 23% of infants during the first year of life. After culture-confirmed <i>S. pyogenes</i> events, the highest IgG increases occurred in children younger than 2 years of age after both pharyngeal and skin disease and asymptomatic carriage at both sites. Higher IgG levels against conserved vaccine antigens correlated with functional activity and were associated with protection from culture-confirmed events after adjustment for age and anti-M protein IgG levels. To our knowledge, our data provide the first evidence of protection associated with humoral immunity to conserved vaccine candidate antigens in humans.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月8日

查看全文
  • Alexander J. Keeley,
  • Fatoumata E. Camara,
  • Edwin P. Armitage,
  • Gabrielle de Crombrugghe,
  • Jainaba Sillah,
  • Modou Lamin Fofana,
  • Victoria Rollinson,
  • Elina Senghore,
  • Musukoi Jammeh,
  • Alana L. Whitcombe,
  • Amat Bittaye,
  • Haddy Ceesay,
  • Isatou Ceesay,
  • Bunja Samateh,
  • Muhammed Manneh,
  • Martina Carducci,
  • Luca Rovetini,
  • Elena Boero,
  • Luisa Massai,
  • Lady Chilel Sanyang,
  • Ousman Camara,
  • Ebrima E. Cessay,
  • Miren Iturriza,
  • Danilo Gomes Moriel,
  • Adam Kucharski,
  • Pierre R. Smeesters,
  • Anne Botteaux,
  • Ya Jankey Jagne,
  • Nicole J. Moreland,
  • Ed Clarke,
  • Beate Kampmann,
  • Michael Marks,
  • Omar Rossi,
  • Henrik Salje,
  • Claire E. Turner,
  • Thushan I. de Silva

摘要

Streptococcus pyogenes leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine development. Here we describe the evolution of serological profiles to conserved vaccine antigens and serotype-specific M proteins from birth and throughout the life course in The Gambia. As placentally transferred IgG waned after birth, serological evidence of new exposure was seen in 23% of infants during the first year of life. After culture-confirmed S. pyogenes events, the highest IgG increases occurred in children younger than 2 years of age after both pharyngeal and skin disease and asymptomatic carriage at both sites. Higher IgG levels against conserved vaccine antigens correlated with functional activity and were associated with protection from culture-confirmed events after adjustment for age and anti-M protein IgG levels. To our knowledge, our data provide the first evidence of protection associated with humoral immunity to conserved vaccine candidate antigens in humans.