Scholarlink

<p>Fibroblasts sculpt the architecture and cellular microenvironments of various tissues. Here we constructed a spatially resolved atlas of human skin fibroblasts from healthy skin and 23 skin diseases, with comparison to 14 cross-tissue diseases. We define six major skin fibroblast subtypes in health and three that are disease-specific. We characterize two fibroblast subtypes further as they are conserved across tissues and are immune-related. The first, F3: fibroblastic reticular cell-like fibroblast (<i>CCL19</i><sup>+</sup><i>CD74</i><sup>+</sup><i>HLA-DRA</i><sup>+</sup>), is a fibroblastic reticular cell-like subtype that is predicted to maintain the superficial perivascular immune niche. The second, F6: inflammatory myofibroblasts (<i>IL11</i><sup>+</sup><i>MMP1</i><sup>+</sup><i>CXCL8</i><sup>+</sup><i>IL7R</i><sup>+</sup>), characterizes early human skin wounds, inflammatory diseases with scarring risk and cancer. F6: inflammatory myofibroblasts were predicted to recruit neutrophils, monocytes and B cells across multiple human tissues. Our study provides a harmonized nomenclature for skin fibroblasts in health and disease, contextualized with cross-tissue findings and clinical skin disease profiles.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月24日

查看全文
  • Lloyd Steele,
  • Bayanne Olabi,
  • Kenny Roberts,
  • Pavel V. Mazin,
  • Simon Koplev,
  • Catherine Tudor,
  • Benjamin Rumney,
  • Chloe Admane,
  • Treasa Jiang,
  • Donovan Correa-Gallegos,
  • Keerthi Priya Chakala,
  • Aljes Binkevich,
  • Nusayhah Hudaa Gopee,
  • Alexander Predeus,
  • Martin Prete,
  • Elena Winheim,
  • Karl Annusver,
  • Agnes Forsthuber,
  • Luc Francis,
  • Sophie Frech,
  • Clarisse Ganier,
  • Thomas Layton,
  • Yingzi Liu,
  • Hao Yuan,
  • Johann E. Gudjonsson,
  • Beate M. Lichtenberger,
  • Satveer Mahil,
  • Jagdeep Nanchahal,
  • Edel A. O’Toole,
  • Maksim V. Plikus,
  • Yuval Rinkevich,
  • Emanuel Rognoni,
  • Catherine H. Smith,
  • Sarah A. Teichmann,
  • Maria Kasper,
  • April R. Foster,
  • Mohammad Lotfollahi,
  • Muzlifah Haniffa

摘要

Fibroblasts sculpt the architecture and cellular microenvironments of various tissues. Here we constructed a spatially resolved atlas of human skin fibroblasts from healthy skin and 23 skin diseases, with comparison to 14 cross-tissue diseases. We define six major skin fibroblast subtypes in health and three that are disease-specific. We characterize two fibroblast subtypes further as they are conserved across tissues and are immune-related. The first, F3: fibroblastic reticular cell-like fibroblast (CCL19+CD74+HLA-DRA+), is a fibroblastic reticular cell-like subtype that is predicted to maintain the superficial perivascular immune niche. The second, F6: inflammatory myofibroblasts (IL11+MMP1+CXCL8+IL7R+), characterizes early human skin wounds, inflammatory diseases with scarring risk and cancer. F6: inflammatory myofibroblasts were predicted to recruit neutrophils, monocytes and B cells across multiple human tissues. Our study provides a harmonized nomenclature for skin fibroblasts in health and disease, contextualized with cross-tissue findings and clinical skin disease profiles.