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<p>DELLA proteins integrate external and internal cues into a signaling network critical for land plant survival. In flowering plants, gibberellins (GAs) induce DELLA recognition to its receptor GID1, resulting in the polyubiquitylation and degradation of DELLA repressors. Notably, bryophytes lack the canonical GA receptor, despite the presence of genes encoding DELLA in these nonvascular land plants. Consequently, the underlying molecular mechanisms of DELLA regulation in bryophytes have remained largely elusive. Here, we report that MpVIH, responsible for the synthesis of inositol pyrophosphate messenger InsP<sub>8</sub>, negatively regulates DELLA in the liverwort <i>Marchantia polymorpha</i> to promote cell division and thallus development. Mechanistically, we elucidate that MpVIH-derived InsP<sub>8</sub> binds to MpDELLA, promoting polyubiquitination and proteasomal degradation of the repressor. Lastly, our study provides evidence for the conservation of inositol pyrophosphate-controlled DELLA degradation in angiosperms. We, thus, identify a ‘noncanonical’ type of DELLA regulation by the inositol pyrophosphate messengers in land plants.</p><p></p>

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GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant

  • 期刊论文

  • 发表日期：

    2025年7月31日

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  • Priyanshi Rana,
  • Anjana Edathil Kadangodan,
  • Paulami Koley,
  • Riya Ghosh,
  • Naga Jyothi Pullagurla,
  • Hemant Chandru Naik,
  • Padmabati Mondal,
  • Srimonta Gayen,
  • Debabrata Laha

摘要

DELLA proteins integrate external and internal cues into a signaling network critical for land plant survival. In flowering plants, gibberellins (GAs) induce DELLA recognition to its receptor GID1, resulting in the polyubiquitylation and degradation of DELLA repressors. Notably, bryophytes lack the canonical GA receptor, despite the presence of genes encoding DELLA in these nonvascular land plants. Consequently, the underlying molecular mechanisms of DELLA regulation in bryophytes have remained largely elusive. Here, we report that MpVIH, responsible for the synthesis of inositol pyrophosphate messenger InsP8, negatively regulates DELLA in the liverwort Marchantia polymorpha to promote cell division and thallus development. Mechanistically, we elucidate that MpVIH-derived InsP8 binds to MpDELLA, promoting polyubiquitination and proteasomal degradation of the repressor. Lastly, our study provides evidence for the conservation of inositol pyrophosphate-controlled DELLA degradation in angiosperms. We, thus, identify a ‘noncanonical’ type of DELLA regulation by the inositol pyrophosphate messengers in land plants.