Scholarlink

<p>Systematic characterization of the molecular states of cells in livestock tissues is essential for understanding the cellular and genetic mechanisms underlying economically and ecologically important physiological traits. Here, as part of the Farm Animal Genotype-Tissue Expression (FarmGTEx) project, we describe a comprehensive reference map including 1,793,854 cells from 59 bovine tissues in calves and adult cattle, spanning both sexes, which reveals intra-tissue and inter-tissue cellular heterogeneity in gene expression, transcription factor regulation and intercellular communication. Integrative analysis with genetic variants that underpin bovine monogenic and complex traits uncovers cell types of relevance, such as spermatocytes, responsible for sperm motility and excitatory neurons for milk fat yield. Comparative analysis reveals similarities in gene expression between cattle and humans, allowing for the detection of relevant cell types to study human complex phenotypes. This Cattle Cell Atlas will serve as a key resource for cattle genetics and genomics, selective breeding and comparative biology.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A multi-tissue single-cell expression atlas in cattle

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月5日

查看全文
  • Bo Han,
  • Houcheng Li,
  • Weijie Zheng,
  • Qi Zhang,
  • Ao Chen,
  • Senlin Zhu,
  • Tao Shi,
  • Fei Wang,
  • Dong Zou,
  • Yu Song,
  • Wen Ye,
  • Aixia Du,
  • Yihan Fu,
  • Minghui Jia,
  • Zhonghao Bai,
  • Zhixiang Yuan,
  • Wansheng Liu,
  • Wenbin Tuo,
  • Jayne C. Hope,
  • David E. MacHugh,
  • John F. O’Grady,
  • Ole Madsen,
  • Goutam Sahana,
  • Yonglun Luo,
  • Lin Lin,
  • Congjun Li,
  • Zexi Cai,
  • Bingjie Li,
  • Jinming Huang,
  • Lin Liu,
  • Zhang Zhang,
  • Zhu Ma,
  • Yali Hou,
  • George E. Liu,
  • Yu Jiang,
  • Hui-zeng Sun,
  • Lingzhao Fang,
  • Dongxiao Sun

摘要

Systematic characterization of the molecular states of cells in livestock tissues is essential for understanding the cellular and genetic mechanisms underlying economically and ecologically important physiological traits. Here, as part of the Farm Animal Genotype-Tissue Expression (FarmGTEx) project, we describe a comprehensive reference map including 1,793,854 cells from 59 bovine tissues in calves and adult cattle, spanning both sexes, which reveals intra-tissue and inter-tissue cellular heterogeneity in gene expression, transcription factor regulation and intercellular communication. Integrative analysis with genetic variants that underpin bovine monogenic and complex traits uncovers cell types of relevance, such as spermatocytes, responsible for sperm motility and excitatory neurons for milk fat yield. Comparative analysis reveals similarities in gene expression between cattle and humans, allowing for the detection of relevant cell types to study human complex phenotypes. This Cattle Cell Atlas will serve as a key resource for cattle genetics and genomics, selective breeding and comparative biology.