Scholarlink

<p>Mouse models of human disease should resemble human genetics. Here we present H2M (human-to-mouse), a computational pipeline to predict mouse genetic variants that mirror the sequence and functional effects of human variants. H2M can also perform mouse-to-human and paralog-to-paralog variant mapping for precision genome-editing tools. We provide a database of &gt;3 million human–mouse mutation pairs, base- and prime-editing libraries for 4,944 variant pairs and a web tool.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Computational prediction of human genetic variants in the mouse genome

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月18日

查看全文
  • Kexin Dong,
  • Samuel I. Gould,
  • Minghang Li,
  • Francisco J. Sánchez Rivera

摘要

Mouse models of human disease should resemble human genetics. Here we present H2M (human-to-mouse), a computational pipeline to predict mouse genetic variants that mirror the sequence and functional effects of human variants. H2M can also perform mouse-to-human and paralog-to-paralog variant mapping for precision genome-editing tools. We provide a database of >3 million human–mouse mutation pairs, base- and prime-editing libraries for 4,944 variant pairs and a web tool.