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<p>A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with previous expectations to initiate movements and make decisions<sup><CitationRef CitationID="CR1">1</CitationRef></sup>. It is difficult to meet this challenge if different laboratories apply different analyses to different recordings in different regions during different behaviours. Here we report a comprehensive set of recordings from 621,733 neurons&#xa0;recorded with 699 Neuropixels probes across 139 mice in 12 laboratories. The data were obtained from mice performing a decision-making task with sensory, motor and cognitive components. The probes covered 279 brain areas in the left forebrain and midbrain and the right hindbrain and cerebellum. We provide an initial appraisal of this brain-wide map and assess how neural activity encodes key task variables. Representations of visual stimuli transiently appeared in classical visual areas after stimulus onset and then spread to ramp-like activity in a collection of midbrain and hindbrain regions that also encoded choices. Neural responses correlated with&#xa0;impending motor action almost everywhere in the brain. Responses to reward delivery and consumption were also widespread. This publicly available dataset represents a resource for understanding how computations distributed across and within brain areas drive behaviour.</p>

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A brain-wide map of neural activity during complex behaviour

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月3日

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  • Leenoy Meshulam,
  • Dora Angelaki,
  • Julius Benson,
  • Isaiah McRoberts,
  • Jean-Paul Noel,
  • Jaime Arlandis,
  • Niccolò Bonacchi,
  • Kcenia Bougrova,
  • Joana A. Catarino,
  • Fanny Cazettes,
  • Davide Crombie,
  • Eric EJ DeWitt,
  • Laura Freitas-Silva,
  • Inês C. Laranjeira,
  • Zachary F. Mainen,
  • Guido T. Meijer,
  • Pranav Rai,
  • Georg Raiser,
  • Florian Rau,
  • Michael M. Schartner,
  • Olivier Winter,
  • Anne E. Urai,
  • Valeria Aguillon-Rodriguez,
  • Cristian Soitu,
  • Anthony M. Zador,
  • Christopher S. Krasniak,
  • Yang Dan,
  • Fei Hu,
  • Brandon Benson,
  • Surya Ganguli,
  • Luigi Acerbi,
  • Gaelle A. Chapuis,
  • Charles Findling,
  • Berk Gercek,
  • Felix Huber,
  • Alexandre Pouget,
  • Hailey Barrell,
  • Dan Birman,
  • Kim Miller,
  • Kai Nylund,
  • Noam Roth,
  • Nicholas A. Steinmetz,
  • Matthew Tucker,
  • Kenneth Yang,
  • Ila Rani Fiete,
  • Ari Liu,
  • Rylan Schaeffer,
  • Anne K. Churchland,
  • Felicia Davatolhagh,
  • Anup Khanal,
  • Maxwell Melin,
  • Masayoshi Murakami,
  • Sophie Denève,
  • Ivan Gordeliy,
  • Mandana Ahmadi,
  • Jaweria Amjad,
  • Naoki Hiratani,
  • Sanjukta Krishnagopal,
  • Peter Latham,
  • Alberto Pezzotta,
  • Zekai Xu,
  • Kush Banga,
  • Jai Bhagat,
  • Mayo Faulkner,
  • Kenneth D. Harris,
  • Michael Krumin,
  • Samuel Picard,
  • Carolina Quadrado,
  • Cyrille Rossant,
  • Miles J. Wells,
  • Lauren E. Wool,
  • Matteo Carandini,
  • Agnès Landemard,
  • Karolina Z. Socha,
  • Sebastian A. Bruijns,
  • Peter Dayan,
  • Julia M. Huntenburg,
  • Debottam Kundu,
  • Farideh Oloomi,
  • Charline Tessereau,
  • Zoe C. Ashwood,
  • Tatiana Engel,
  • Robert Fetcho,
  • Laura M. Haetzel,
  • Christopher Langdon,
  • Brenna McMannon,
  • Zeinab Mohammadi,
  • Alejandro Pan Vazquez,
  • Jonathan W. Pillow,
  • Nicholas A. Roy,
  • Yanliang Shi,
  • Ilana B. Witten,
  • Robert Campbell,
  • Naureen Ghani,
  • Sonja B. Hofer,
  • Hernando Martinez-Vergara,
  • Nathaniel J. Miska,
  • Thomas Mrsic-Flogel,
  • Steven J. West,
  • Yaxuan Yang,
  • Karel Svoboda,
  • Marsa Taheri,
  • Michael Häusser,
  • Petrina Y. P. Lau,
  • Amalia Makri-Cottington,
  • Sabrina Perrenoud,
  • Larry Abbot,
  • Hannah M. Bayer,
  • Julien Boussard,
  • E. Kelly Buchanan,
  • Michele Fabbri,
  • Cole Hurwitz,
  • Christopher Langfield,
  • Hyun Dong Lee,
  • Catalin Mitelut,
  • Liam Paninski,
  • Kamron Saniee,
  • Erdem Varol,
  • Shuqi Wang,
  • Matthew R. Whiteway,
  • Charles Windolf,
  • Han Yu,
  • Yizi Zhang,
  • Dora Angelaki,
  • Brandon Benson,
  • Julius Benson,
  • Daniel Birman,
  • Niccolò Bonacchi,
  • Kcénia Bougrova,
  • Sebastian A. Bruijns,
  • Matteo Carandini,
  • Joana A. Catarino,
  • Gaelle A. Chapuis,
  • Anne K. Churchland,
  • Yang Dan,
  • Felicia Davatolhagh,
  • Peter Dayan,
  • Eric EJ DeWitt,
  • Tatiana A. Engel,
  • Michele Fabbri,
  • Mayo Faulkner,
  • Ila Rani Fiete,
  • Charles Findling,
  • Laura Freitas-Silva,
  • Berk Gerçek,
  • Kenneth D. Harris,
  • Michael Häusser,
  • Sonja B. Hofer,
  • Fei Hu,
  • Félix Hubert,
  • Julia M. Huntenburg,
  • Anup Khanal,
  • Christopher S. Krasniak,
  • Christopher Langdon,
  • Christopher Langfield,
  • Petrina Y. P. Lau,
  • Zachary F. Mainen,
  • Guido T. Meijer,
  • Nathaniel J. Miska,
  • Thomas D. Mrsic-Flogel,
  • Jean-Paul Noel,
  • Kai Nylund,
  • Alejandro Pan-Vazquez,
  • Liam Paninski,
  • Alexandre Pouget,
  • Cyrille Rossant,
  • Noam Roth,
  • Rylan Schaeffer,
  • Michael Schartner,
  • Yanliang Shi,
  • Karolina Z. Socha,
  • Nicholas A. Steinmetz,
  • Karel Svoboda,
  • Anne E. Urai,
  • Miles J. Wells,
  • Steven J. West,
  • Matthew R. Whiteway,
  • Olivier Winter,
  • Ilana B. Witten

摘要

A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with previous expectations to initiate movements and make decisions1. It is difficult to meet this challenge if different laboratories apply different analyses to different recordings in different regions during different behaviours. Here we report a comprehensive set of recordings from 621,733 neurons recorded with 699 Neuropixels probes across 139 mice in 12 laboratories. The data were obtained from mice performing a decision-making task with sensory, motor and cognitive components. The probes covered 279 brain areas in the left forebrain and midbrain and the right hindbrain and cerebellum. We provide an initial appraisal of this brain-wide map and assess how neural activity encodes key task variables. Representations of visual stimuli transiently appeared in classical visual areas after stimulus onset and then spread to ramp-like activity in a collection of midbrain and hindbrain regions that also encoded choices. Neural responses correlated with impending motor action almost everywhere in the brain. Responses to reward delivery and consumption were also widespread. This publicly available dataset represents a resource for understanding how computations distributed across and within brain areas drive behaviour.