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<p>Human stem cell-based embryo models (hSCBEMs) are emerging as powerful tools in biomedical research owing to their ability to recapitulate the cellular, molecular and structural features of human embryos. These models offer new opportunities to advance our understanding of embryogenesis and to&#xa0;find applications in assisted reproduction, regenerative medicine, precision medicine and drug development. Despite rapid progress, challenges remain in improving the structural, cellular and molecular fidelity, efficiency and standardization of hSCBEMs. This Review discusses recent advances in the development of hSCBEMs and key challenges in their construction and applications, and highlights their translational potential while emphasizing the importance of ethical frameworks and public engagement.</p>

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Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Hao Wu,
  • Hongmei Wang

摘要

Human stem cell-based embryo models (hSCBEMs) are emerging as powerful tools in biomedical research owing to their ability to recapitulate the cellular, molecular and structural features of human embryos. These models offer new opportunities to advance our understanding of embryogenesis and to find applications in assisted reproduction, regenerative medicine, precision medicine and drug development. Despite rapid progress, challenges remain in improving the structural, cellular and molecular fidelity, efficiency and standardization of hSCBEMs. This Review discusses recent advances in the development of hSCBEMs and key challenges in their construction and applications, and highlights their translational potential while emphasizing the importance of ethical frameworks and public engagement.