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<p><i>Klebsiella</i> spp. are pathobionts associated with acute infections, including pneumonia and infections in the urinary tract and bloodstream, often acquired in health-care settings. They represent a global threat owing to the prevalence of multidrug-resistant strains. Moreover, <i>Klebsiella</i> spp., similarly to other members of the human gut microbiota, can contribute to the pathogenesis of non-communicable disorders. In this Review, we describe the taxonomical and molecular characteristics of the <i>Klebsiella</i> genus, as well as its epidemiology and impact as an infectious agent. We also review current evidence that associates <i>Klebsiella</i> spp. with different non-communicable disorders, including chronic inflammatory and metabolic disorders and cancer. We discuss different approaches to target <i>Klebsiella</i> spp., including tailored antibiotics, faecal microbiota transplantation, live biotherapeutic products and bacteriophages. Finally, we discuss the importance of preventative measures, such as epidemiological surveillance, infection control practices and lifestyle interventions, to reduce the spread of <i>Klebsiella</i> spp. in health-care settings and the broader community.</p>

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Klebsiella genus as driver of human disease: from infections to non-communicable disorders

  • 期刊论文

  • 发表日期：

    2026年6月22日

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  • Serena Porcari,
  • Margherita Ferrari,
  • Anna Melekhova,
  • Andrea Severino,
  • William Fusco,
  • Aurora Sveva Carlà,
  • Flavio De Maio,
  • Herbert Tilg,
  • Antonio Gasbarrini,
  • Eran Elinav,
  • Gianluca Ianiro

摘要

Klebsiella spp. are pathobionts associated with acute infections, including pneumonia and infections in the urinary tract and bloodstream, often acquired in health-care settings. They represent a global threat owing to the prevalence of multidrug-resistant strains. Moreover, Klebsiella spp., similarly to other members of the human gut microbiota, can contribute to the pathogenesis of non-communicable disorders. In this Review, we describe the taxonomical and molecular characteristics of the Klebsiella genus, as well as its epidemiology and impact as an infectious agent. We also review current evidence that associates Klebsiella spp. with different non-communicable disorders, including chronic inflammatory and metabolic disorders and cancer. We discuss different approaches to target Klebsiella spp., including tailored antibiotics, faecal microbiota transplantation, live biotherapeutic products and bacteriophages. Finally, we discuss the importance of preventative measures, such as epidemiological surveillance, infection control practices and lifestyle interventions, to reduce the spread of Klebsiella spp. in health-care settings and the broader community.