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<p>Metabolic dysfunction-associated steatotic liver disease, and the broader spectrum of steatotic liver disease (SLD), require tailored lifestyle interventions across different age groups, considering genetics, family involvement, and psychological, environmental and social factors. Clinical practice guidelines for adults typically recommend a uniform treatment approach, regardless of age-related considerations. However, different emphases might be needed for pregnant women, adults and the older age group (≥65 years of age). Moreover, metabolic health, and therefore liver health, are determined at a very early age and even in utero and infancy. Thus, the prevention and treatment of SLD should not be overlooked at these early life stages and should be specific for each stage of life. The life course approach is a comprehensive strategy that considers health needs across all stages of life, from infancy to older age. This Review puts the spotlight on these topics, creating a comprehensive age-chronological order overview of the literature, addressing gaps in knowledge, providing practical advice and highlighting age-related considerations, in contrast to a one-size-fits-all (ages) approach.</p>

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Lifespan approaches for the prevention and management of steatotic liver disease

  • 期刊论文

  • 发表日期：

    2026年4月15日

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  • Shira Zelber-Sagi,
  • Dana Ivancovsky-Wajcman,
  • Carina Kugelmas,
  • Ali A. Weinstein,
  • Vincent Wai-Sun Wong,
  • Laurent Castera,
  • J. Bernadette Moore,
  • Marialena Mouzaki,
  • Kate Hallsworth,
  • James M. Paik,
  • Jeffrey B. Schwimmer,
  • Lynn H. Gerber,
  • Zobair M. Younossi

摘要

Metabolic dysfunction-associated steatotic liver disease, and the broader spectrum of steatotic liver disease (SLD), require tailored lifestyle interventions across different age groups, considering genetics, family involvement, and psychological, environmental and social factors. Clinical practice guidelines for adults typically recommend a uniform treatment approach, regardless of age-related considerations. However, different emphases might be needed for pregnant women, adults and the older age group (≥65 years of age). Moreover, metabolic health, and therefore liver health, are determined at a very early age and even in utero and infancy. Thus, the prevention and treatment of SLD should not be overlooked at these early life stages and should be specific for each stage of life. The life course approach is a comprehensive strategy that considers health needs across all stages of life, from infancy to older age. This Review puts the spotlight on these topics, creating a comprehensive age-chronological order overview of the literature, addressing gaps in knowledge, providing practical advice and highlighting age-related considerations, in contrast to a one-size-fits-all (ages) approach.