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<p>Repurposing of existing drugs for new indications has attracted substantial attention owing to its potential to accelerate drug development and reduce costs. Hundreds of computational resources such as databases and predictive platforms have been developed that can be applied for drug repurposing, making it challenging to select the right resource for a specific drug repurposing project. With the aim of helping to address this challenge, here we overview computational approaches to drug repurposing based on a comprehensive survey of available in silico resources using a purpose-built drug repurposing ontology that classifies the resources into hierarchical categories and provides application-specific information. We also present an expert evaluation of selected resources and three drug repurposing case studies implemented within the Horizon Europe REMEDi4ALL project to demonstrate the practical use of the resources. This comprehensive Review with expert evaluations and case studies provides guidelines and recommendations on the best use of various in silico resources for drug repurposing and establishes a basis for a sustainable and extendable drug repurposing web catalogue.</p>

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Computational drug repurposing: approaches, evaluation of in silico resources and case studies

  • 期刊论文

  • 发表日期：

    2025年3月18日

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  • Ziaurrehman Tanoli,
  • Adrià Fernández-Torras,
  • Umut Onur Özcan,
  • Aleksandr Kushnir,
  • Kristen Michelle Nader,
  • Yojana Gadiya,
  • Laura Fiorenza,
  • Aleksandr Ianevski,
  • Markus Vähä-Koskela,
  • Mitro Miihkinen,
  • Umair Seemab,
  • Henri Leinonen,
  • Brinton Seashore-Ludlow,
  • Marianna Tampere,
  • Adelinn Kalman,
  • Flavio Ballante,
  • Emilio Benfenati,
  • Gary Saunders,
  • Swapnil Potdar,
  • Ismael Gómez García,
  • Ricard García-Serna,
  • Carmine Talarico,
  • Andrea Rosario Beccari,
  • Wesley Schaal,
  • Andrea Polo,
  • Susan Costantini,
  • Enrico Cabri,
  • Marc Jacobs,
  • Jani Saarela,
  • Alfredo Budillon,
  • Ola Spjuth,
  • Päivi Östling,
  • Henri Xhaard,
  • Jordi Quintana,
  • Jordi Mestres,
  • Philip Gribbon,
  • Anton E. Ussi,
  • Donald C. Lo,
  • Martin de Kort,
  • Krister Wennerberg,
  • Maddalena Fratelli,
  • Jordi Carreras-Puigvert,
  • Tero Aittokallio

摘要

Repurposing of existing drugs for new indications has attracted substantial attention owing to its potential to accelerate drug development and reduce costs. Hundreds of computational resources such as databases and predictive platforms have been developed that can be applied for drug repurposing, making it challenging to select the right resource for a specific drug repurposing project. With the aim of helping to address this challenge, here we overview computational approaches to drug repurposing based on a comprehensive survey of available in silico resources using a purpose-built drug repurposing ontology that classifies the resources into hierarchical categories and provides application-specific information. We also present an expert evaluation of selected resources and three drug repurposing case studies implemented within the Horizon Europe REMEDi4ALL project to demonstrate the practical use of the resources. This comprehensive Review with expert evaluations and case studies provides guidelines and recommendations on the best use of various in silico resources for drug repurposing and establishes a basis for a sustainable and extendable drug repurposing web catalogue.