Scholarlink

<p>To meet demand for bioactive, homogeneously modified peptides for both fundamental research and therapeutic development, synthetic methods that are programmable, broadly applicable and inherently sustainable are urgently needed. The mild reaction conditions and precise tunability of electrochemical transformations provide appealing opportunities to carefully navigate the rich redox-active landscape of canonical and non-canonical amino acid functionalities. Modern technological breakthroughs in synthetic electro-organic chemistry are further expanding capabilities, propelling the field of electrochemical peptide modifications into an era of accelerating innovation. This Review highlights recent advances (2020–present) in electrochemical peptide synthesis and residue-specific modifications in a graphically rich format that emphasizes the expanding diversity of available electrochemical strategies and their broader compatibility with complex peptide substrates. Outstanding challenges and opportunities for further innovation are discussed.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Advances in electrochemical peptide synthesis and modification

  • 期刊论文

  • 发表日期：

    2026年6月25日

查看全文
  • Dhanya Karipal Padinjare Veedu,
  • Flynn C. Attard,
  • Esteban Suárez-Picado,
  • Saurabh K. Ahirwar,
  • Lara R. Malins

摘要

To meet demand for bioactive, homogeneously modified peptides for both fundamental research and therapeutic development, synthetic methods that are programmable, broadly applicable and inherently sustainable are urgently needed. The mild reaction conditions and precise tunability of electrochemical transformations provide appealing opportunities to carefully navigate the rich redox-active landscape of canonical and non-canonical amino acid functionalities. Modern technological breakthroughs in synthetic electro-organic chemistry are further expanding capabilities, propelling the field of electrochemical peptide modifications into an era of accelerating innovation. This Review highlights recent advances (2020–present) in electrochemical peptide synthesis and residue-specific modifications in a graphically rich format that emphasizes the expanding diversity of available electrochemical strategies and their broader compatibility with complex peptide substrates. Outstanding challenges and opportunities for further innovation are discussed.