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<p>Early-life microbial exposures shape immune development and allergy risk. Food allergen sensitization, reflected by the presence of food allergen-specific immunoglobulin E (IgE), is an early indication of impaired immune tolerance. Here we show that early-life transmission of aromatic lactate-producing bifidobacteria strains in 147 children followed from birth to 5 years of age, facilitated by vaginal delivery, exposure to older siblings and exclusive breastfeeding for the first 2 months, led to increased levels of aromatic lactates in the infant gut. This microbiota–metabolite signature was inversely associated with the development of food allergen-specific IgE until 5 years and atopic dermatitis at 2 years. The observed effect was mediated by 4-hydroxy-phenyllactate, which inhibited IgE, but not IgG, production in ex vivo human immune cell cultures. Together, these findings define an early-life microbiota–metabolite–immune axis linking microbial transmission and feeding practices with reduced allergic sensitization.</p>

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Early-life colonization by aromatic-lactate-producing bifidobacteria lowers the risk of allergic sensitization

  • 期刊论文

  • 发表日期：

    2026年1月12日

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  • Pernille Neve Myers,
  • Rasmus Kaae Dehli,
  • Axel Mie,
  • Janne Marie Moll,
  • Henrik Munch Roager,
  • Carsten Eriksen,
  • Martin Frederik Laursen,
  • Ellen Magdalena Staudinger,
  • Ioanna Chatzigiannidou,
  • Pi Lærke Johansen,
  • Niels van Best,
  • Martin O’Hely,
  • Daniel Andersen,
  • Nadja Lund Nørregaard,
  • Mikael Pedersen,
  • Eckard Hamelmann,
  • Susanne Lau,
  • Martin Iain Bahl,
  • Maher Abou Hachem,
  • Tine Rask Licht,
  • Henrik Bjørn Nielsen,
  • Anna Hammerich Thysen,
  • Peter Vuillermin,
  • John Penders,
  • Karsten Kristiansen,
  • Annika Scheynius,
  • Johan Alm,
  • Susanne Brix

摘要

Early-life microbial exposures shape immune development and allergy risk. Food allergen sensitization, reflected by the presence of food allergen-specific immunoglobulin E (IgE), is an early indication of impaired immune tolerance. Here we show that early-life transmission of aromatic lactate-producing bifidobacteria strains in 147 children followed from birth to 5 years of age, facilitated by vaginal delivery, exposure to older siblings and exclusive breastfeeding for the first 2 months, led to increased levels of aromatic lactates in the infant gut. This microbiota–metabolite signature was inversely associated with the development of food allergen-specific IgE until 5 years and atopic dermatitis at 2 years. The observed effect was mediated by 4-hydroxy-phenyllactate, which inhibited IgE, but not IgG, production in ex vivo human immune cell cultures. Together, these findings define an early-life microbiota–metabolite–immune axis linking microbial transmission and feeding practices with reduced allergic sensitization.