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<p>Scalable approaches such as digital cognitive-behavioural therapy guided self-help (D-CBTgsh) may help close the treatment gap for college students with mental disorders. In a randomized clinical trial (ClinicalTrials.gov: NCT04162847) across 26 US colleges, populations were offered a mental health screen (39,194 assessed). Students with clinical levels or high risk for anxiety, depression and/or eating disorders (<i>N</i> = 6,205) were randomized to screening+D-CBTgsh or screening+referral-to-college-provided-care groups. Screening+D-CBTgsh reduced prevalence of any mental disorder (primary outcome) at 6 weeks (odds ratio (OR) = 0.80, 95% CI = 0.70–0.91), 6 months (OR = 0.77, 95% CI = 0.68–0.88) and 2 years (OR = 0.82, 95% CI = 0.72–0.93). Services uptake was greater in screening+D-CBTgsh (74.4%) versus screening+referral (30.2%) at 6 months (OR = 6.72, 95% CI = 6.01–7.52) and 2 years (OR = 1.83, 95% CI = 1.64–2.04), including for minoritized groups. Screening+D-CBTgsh (versus screening+referral to college-provided care) also improved dimensional outcomes of generalized anxiety, social anxiety, depression, eating disorder symptoms and mental health functioning. Findings supported transdiagnostic prevention and intervention benefits of screening+D-CBTgsh and its viability as a scalable, population-based approach.</p>

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Population-based RCT of a digital cognitive-behavioural guided self-help intervention for anxiety, depression and eating disorders in college students

  • 期刊论文

  • 发表日期：

    2026年5月7日

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  • Michelle G. Newman,
  • Ellen E. Fitzsimmons-Craft,
  • Seung Yeon Baik,
  • Nur Hani Zainal,
  • Adam Calderon,
  • Gavin N. Rackoff,
  • Marie-Laure Firebaugh,
  • Elsa Rojas-Ashe,
  • Yan Leykin,
  • Daphne Lew,
  • Daniel Eisenberg,
  • C. Barr Taylor,
  • Denise E. Wilfley

摘要

Scalable approaches such as digital cognitive-behavioural therapy guided self-help (D-CBTgsh) may help close the treatment gap for college students with mental disorders. In a randomized clinical trial (ClinicalTrials.gov: NCT04162847) across 26 US colleges, populations were offered a mental health screen (39,194 assessed). Students with clinical levels or high risk for anxiety, depression and/or eating disorders (N = 6,205) were randomized to screening+D-CBTgsh or screening+referral-to-college-provided-care groups. Screening+D-CBTgsh reduced prevalence of any mental disorder (primary outcome) at 6 weeks (odds ratio (OR) = 0.80, 95% CI = 0.70–0.91), 6 months (OR = 0.77, 95% CI = 0.68–0.88) and 2 years (OR = 0.82, 95% CI = 0.72–0.93). Services uptake was greater in screening+D-CBTgsh (74.4%) versus screening+referral (30.2%) at 6 months (OR = 6.72, 95% CI = 6.01–7.52) and 2 years (OR = 1.83, 95% CI = 1.64–2.04), including for minoritized groups. Screening+D-CBTgsh (versus screening+referral to college-provided care) also improved dimensional outcomes of generalized anxiety, social anxiety, depression, eating disorder symptoms and mental health functioning. Findings supported transdiagnostic prevention and intervention benefits of screening+D-CBTgsh and its viability as a scalable, population-based approach.