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<p>The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system disintegrates, brain dynamics become more difficult to control. Both effects are reversed upon re-awakening induced by thalamic deep-brain stimulation in the macaque. Regional breakdown of integrated information coincides with the species-specific spatial topography of <i>PVALB/Pvalb</i> gene expression. To provide mechanistic insight beyond correlation, we develop computational models for humans, macaques and mice that integrate species-specific connectivity and transcriptomic gradients, demonstrating their respective roles for controlling brain dynamics and information integration. We reveal evolutionarily conserved controllers of information integration in the mammalian brain.</p>

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Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月28日

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  • Andrea I. Luppi,
  • Lynn Uhrig,
  • Jordy Tasserie,
  • Pedro A. M. Mediano,
  • Fernando E. Rosas,
  • S. Parker Singleton,
  • Daniel Gutierrez-Barragan,
  • Silvia Gini,
  • Pablo Castro,
  • Camilo M. Signorelli,
  • Daniel Golkowski,
  • Andreas Ranft,
  • Rüdiger Ilg,
  • Denis Jordan,
  • Kanako Muta,
  • Junichi Hata,
  • Hideyuki Okano,
  • Zhen-Qi Liu,
  • Yohan Yee,
  • Alain Destexhe,
  • Rodrigo Cofre,
  • David K. Menon,
  • Alessandro Gozzi,
  • Bechir Jarraya,
  • Emmanuel A. Stamatakis

摘要

The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system disintegrates, brain dynamics become more difficult to control. Both effects are reversed upon re-awakening induced by thalamic deep-brain stimulation in the macaque. Regional breakdown of integrated information coincides with the species-specific spatial topography of PVALB/Pvalb gene expression. To provide mechanistic insight beyond correlation, we develop computational models for humans, macaques and mice that integrate species-specific connectivity and transcriptomic gradients, demonstrating their respective roles for controlling brain dynamics and information integration. We reveal evolutionarily conserved controllers of information integration in the mammalian brain.