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<p>School interventions targeting adolescents’ general knowledge of vaccination are rare despite their potential to reduce vaccine hesitancy. This cluster-randomized trial involving 8,589 French ninth graders from 399 schools tests two interventions against the standard curriculum. The first provided teachers with ready-to-use pedagogical activities, while the second used a chatbot. Both interventions significantly improved adolescents’ attitudes towards vaccination, the primary outcome of this trial (Pedagogical Activities: <i>t</i><sub>398</sub> = 2.99; <i>P</i> = 0.003; <i>β</i> = 0.094; 95% confidence interval (CI), (0.032, 0.156); Chatbot: <i>t</i><sub>398</sub> = 2.07; <i>P</i> = 0.039; <i>β</i> = 0.063; 95% CI, (0.003, 0.124)). Both also improved pupils’ knowledge of vaccination (Pedagogical Activities: <i>t</i><sub>398</sub> = 3.23; <i>P</i> = 0.0013; <i>β</i> = 0.103; 95% CI, (0.040, 0.165); Chatbot: <i>t</i><sub>398</sub> = 2.23; <i>P</i> = 0.027; <i>β</i> = 0.070; 95% CI, (0.008, 0.132)). That such interventions can improve pupils’ acceptance and understanding of vaccines has important consequences for public health.</p>

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Interventions to reduce vaccine hesitancy among adolescents: a cluster-randomized trial

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • N. Baudouin,
  • S. de Rouilhan,
  • E. Huillery,
  • E. Pasquinelli,
  • C. Chevallier,
  • H. Mercier

摘要

School interventions targeting adolescents’ general knowledge of vaccination are rare despite their potential to reduce vaccine hesitancy. This cluster-randomized trial involving 8,589 French ninth graders from 399 schools tests two interventions against the standard curriculum. The first provided teachers with ready-to-use pedagogical activities, while the second used a chatbot. Both interventions significantly improved adolescents’ attitudes towards vaccination, the primary outcome of this trial (Pedagogical Activities: t398 = 2.99; P = 0.003; β = 0.094; 95% confidence interval (CI), (0.032, 0.156); Chatbot: t398 = 2.07; P = 0.039; β = 0.063; 95% CI, (0.003, 0.124)). Both also improved pupils’ knowledge of vaccination (Pedagogical Activities: t398 = 3.23; P = 0.0013; β = 0.103; 95% CI, (0.040, 0.165); Chatbot: t398 = 2.23; P = 0.027; β = 0.070; 95% CI, (0.008, 0.132)). That such interventions can improve pupils’ acceptance and understanding of vaccines has important consequences for public health.