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<p>Trait similarities between spouses are a key factor that shapes the landscape of complex human traits. The driving force behind the spousal correlations can increase the overall prevalence of disorders, influence occurrences of comorbidities and bias estimations of genetic architectures. However, there is a lack of large-scale studies examining cultural differences and generational trends in spousal correlations for psychiatric disorders. Focusing on three national registries, we performed a large-scale analysis on spousal correlations across nine psychiatric disorders. We obtained the trait correlations from five million spousal pairs in Taiwan and then compared them with estimates from the Danish national registry (571,534 pairs) and with published results from the Swedish national registry (707,263 pairs). Generational changes in Taiwan for people born after the 1930s were investigated as well. We found that a majority of psychiatric disorders have consistent spousal correlations across nations and over generations, indicating their importance in the population dynamics of psychiatric disorders.</p>

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Spousal correlations for nine psychiatric disorders are consistent across cultures and persistent over generations

  • 期刊论文

  • 发表日期：

    2025年8月28日

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  • Chun Chieh Fan,
  • Saeid Rasekhi Dehkordi,
  • Richard Border,
  • Lucy Shao,
  • Bohan Xu,
  • Robert Loughnan,
  • Wesley K. Thompson,
  • Le-Yin Hsu,
  • Mei-Chen Lin,
  • Chi-Fung Cheng,
  • Rou-Yi Lai,
  • Mei-Hsin Su,
  • Wei-Yi Kao,
  • Thomas Werge,
  • Chi-Shin Wu,
  • Andrew J. Schork,
  • Noah Zaitlen,
  • Alfonso Buil Demur,
  • Shi-Heng Wang

摘要

Trait similarities between spouses are a key factor that shapes the landscape of complex human traits. The driving force behind the spousal correlations can increase the overall prevalence of disorders, influence occurrences of comorbidities and bias estimations of genetic architectures. However, there is a lack of large-scale studies examining cultural differences and generational trends in spousal correlations for psychiatric disorders. Focusing on three national registries, we performed a large-scale analysis on spousal correlations across nine psychiatric disorders. We obtained the trait correlations from five million spousal pairs in Taiwan and then compared them with estimates from the Danish national registry (571,534 pairs) and with published results from the Swedish national registry (707,263 pairs). Generational changes in Taiwan for people born after the 1930s were investigated as well. We found that a majority of psychiatric disorders have consistent spousal correlations across nations and over generations, indicating their importance in the population dynamics of psychiatric disorders.