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<p>With the worldwide increase in only-child families, it is crucial to understand the effects of growing up without siblings (GWS) on the adult brain, behaviour and the underlying pathways. Using the CHIMGEN cohort, we investigated the associations of GWS with adult brain structure, function, connectivity, cognition, personality and mental health, as well as the pathway from GWS to GWS-related growth environments to brain and to behaviour development, in 2,397 pairs of individuals with and without siblings well matched in covariates. We found associations linking GWS to higher language fibre integrity, lower motor fibre integrity, larger cerebellar volume, smaller cerebral volume and lower frontotemporal spontaneous brain activity. Contrary to the stereotypical impression of associations between GWS and problem behaviours, we found positive correlations of GWS with neurocognition and mental health. Despite direct effects, GWS affects most brain and behavioural outcomes through modifiable environments, such as socioeconomic status, maternal care and family support, suggesting targets for interventions to enhance children’s healthy growth.</p>

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How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

  • 期刊论文

  • 发表日期：

    2025年3月31日

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  • Jie Tang,
  • Jing Zhang,
  • Wei Li,
  • Meiyun Wang,
  • Jingliang Cheng,
  • Bing Zhang,
  • Wenzhen Zhu,
  • Shijun Qiu,
  • Guangbin Cui,
  • Yongqiang Yu,
  • Weihua Liao,
  • Hui Zhang,
  • Bo Gao,
  • Xiaojun Xu,
  • Yunjun Yang,
  • Tong Han,
  • Zhenwei Yao,
  • Quan Zhang,
  • Wen Qin,
  • Feng Liu,
  • Meng Liang,
  • Sijia Wang,
  • Qiang Xu,
  • Jiayuan Xu,
  • Jilian Fu,
  • Yuan Ji,
  • Nana Liu,
  • Peng Zhang,
  • Dapeng Shi,
  • Caihong Wang,
  • Su Lui,
  • Zhihan Yan,
  • Feng Chen,
  • Wen Shen,
  • Yanwei Miao,
  • Dawei Wang,
  • Junfang Xian,
  • Xiaochu Zhang,
  • Kai Xu,
  • Xi-Nian Zuo,
  • Longjiang Zhang,
  • Zhaoxiang Ye,
  • Zuojun Geng,
  • Jia-Hong Gao,
  • Chunshui Yu,
  • Quan Zhang,
  • Junping Wang,
  • Xue Zhang,
  • Xinjun Suo,
  • Congcong Yuan,
  • Hui Xue,
  • Tianying Gao,
  • Junpeng Liu,
  • Yanjun Li,
  • Xi Guo,
  • Lixue Xu,
  • Jiajia Zhu,
  • Huaigui Liu,
  • Fangshi Zhao,
  • Jie Sun,
  • Yongjie Xu,
  • Huanhuan Cai,
  • Yaodan Zhang,
  • Yongqin Xiong,
  • Xianting Sun,
  • Nannan Pan,
  • Xue Zhang Jr,
  • Jiayang Yang,
  • Ya Wen,
  • Dan Zhu,
  • Bingjie Wu,
  • Wenshuang Zhu,
  • Qingqing Diao,
  • Yujuan Cao,
  • Bingbing Yang,
  • Lining Guo,
  • Yingying Xie,
  • Jiahui Lin,
  • Zhimin Li,
  • Yan Zhang,
  • Kaizhong Xue,
  • Zirui Wang,
  • Junlin Shen,
  • Xuejun Zhang,
  • Hao Ding,
  • Qian Su,
  • Mulin Jun Li,
  • Shijie Zhang,
  • Lun Ma,
  • Yan Bai,
  • Min Guan,
  • Wei Wei,
  • Peifang Miao,
  • Fuhong Duan,
  • Yafei Guo,
  • Weijian Wang,
  • Long Jiang Zhang,
  • Lijuan Zheng,
  • Lilin,
  • Yunfei Wang,
  • Han Zhang,
  • Xinyuan Zhang,
  • Zhao Qing,
  • Sichu Wu,
  • Junxia Wang,
  • Yi Sun,
  • Yang He,
  • Xi-Nian Zuo,
  • Zhe Zhang,
  • Yin-Shan Wang,
  • Quan Zhou,
  • Tian Tian,
  • Yi Liang,
  • Yujie Liu,
  • Hui Zeng,
  • Jingxian Chen,
  • Haitao Ge,
  • Peng Xu,
  • Cailuan Lu,
  • Chen Wu,
  • Xiaoying Yang,
  • Yuzhao Wang,
  • Yankai Wu,
  • Xuran Feng,
  • Ling Li,
  • Duo Gao,
  • Rujing Zha,
  • Ying Li,
  • Lizhuang Yang,
  • Ying Chen,
  • Ling Zuo,
  • Jianqiao Ge,
  • Guoyuan Yang,
  • Wen Wang,
  • Linfeng Yan,
  • Yang Yang,
  • Jin Zhang,
  • Qian Wang,
  • Xiaoxia Qu,
  • Ying Wang,
  • Fei Yuan,
  • Li Hu,
  • Jizhen Li,
  • Weiwei Wang,
  • Yujing Zhou,
  • Miaomiao Long,
  • Lihua Liu,
  • Xiaohu Li,
  • Xiaoshu Li,
  • Jiance Li,
  • Nengzhi Xia,
  • Weihua Liao,
  • Shuai Yang,
  • Youming Zhang,
  • Jing Zhang,
  • Guangyao Liu,
  • Laiyang Ma,
  • Xiaochun Wang,
  • Ying Lei,
  • Bo Gao,
  • Gang Zhang,
  • Kang Yuan,
  • Jingjing Xu,
  • Xiaojun Guan,
  • Yuankai Lin,
  • Hui Juan Chen,
  • Yuchuan Fu,
  • Yi Lu,
  • Jun Guo,
  • Hao Lu,
  • Yue Wu

摘要

With the worldwide increase in only-child families, it is crucial to understand the effects of growing up without siblings (GWS) on the adult brain, behaviour and the underlying pathways. Using the CHIMGEN cohort, we investigated the associations of GWS with adult brain structure, function, connectivity, cognition, personality and mental health, as well as the pathway from GWS to GWS-related growth environments to brain and to behaviour development, in 2,397 pairs of individuals with and without siblings well matched in covariates. We found associations linking GWS to higher language fibre integrity, lower motor fibre integrity, larger cerebellar volume, smaller cerebral volume and lower frontotemporal spontaneous brain activity. Contrary to the stereotypical impression of associations between GWS and problem behaviours, we found positive correlations of GWS with neurocognition and mental health. Despite direct effects, GWS affects most brain and behavioural outcomes through modifiable environments, such as socioeconomic status, maternal care and family support, suggesting targets for interventions to enhance children’s healthy growth.