Scholarlink

<p>The brain offers a unique environment for cancer, with limited access to nutrients and highly regulated immune surveillance. Here we explore the role of ferroptosis, a form of metabolically regulated cell death driven by iron-mediated lipid peroxidation, in shaping immune-cell composition and function in glial tumours. We review the complex metabolic crosstalk between cell populations regulating ferroptosis in the glioma milieu. Ferroptosis induces polarization of resident microglia and controls the cytotoxic roles of CD8<sup>+</sup> T cells and the immunosuppressive effects of regulatory T cells. We discuss recently uncovered mechanisms of ferroptosis-driven immune evasion and the impact on tumour evolution. Additionally, we analyse mechanisms of synergy in combinations incorporating ferroptosis-inducing agents and immunotherapies, including immune checkpoint blockade and adoptive cell therapies, which aim to induce effective immune responses and durable control in gliomas.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Emerging roles of ferroptosis in modulating the immune landscape of glial tumours

  • 期刊论文

  • 发表日期：

    2026年6月1日

查看全文
  • Michael G. Argenziano,
  • Taruna V. Neelakantan,
  • Colin Sperring,
  • Oluwaseyi Adeuyan,
  • Dominique M. O. Higgins,
  • Jeffrey N. Bruce,
  • Betty Y. S. Kim,
  • Athanassios Dovas,
  • Peter Canoll,
  • Michael Lim,
  • Brent R. Stockwell,
  • Matei A. Banu

摘要

The brain offers a unique environment for cancer, with limited access to nutrients and highly regulated immune surveillance. Here we explore the role of ferroptosis, a form of metabolically regulated cell death driven by iron-mediated lipid peroxidation, in shaping immune-cell composition and function in glial tumours. We review the complex metabolic crosstalk between cell populations regulating ferroptosis in the glioma milieu. Ferroptosis induces polarization of resident microglia and controls the cytotoxic roles of CD8+ T cells and the immunosuppressive effects of regulatory T cells. We discuss recently uncovered mechanisms of ferroptosis-driven immune evasion and the impact on tumour evolution. Additionally, we analyse mechanisms of synergy in combinations incorporating ferroptosis-inducing agents and immunotherapies, including immune checkpoint blockade and adoptive cell therapies, which aim to induce effective immune responses and durable control in gliomas.