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<p>The inflammatory process resulting in the fibrotic encapsulation of implants has been well studied. However, how acellular dermal matrix (ADM) used in breast reconstruction elicits an attenuated foreign-body response (FBR) remains unclear. Here, by leveraging single-cell RNA-sequencing and proteomic data from pairs of fibrotically encapsulated specimens (bare silicone and silicone wrapped with ADM) collected from individuals undergoing breast reconstruction, we show that high levels of the extracellular-matrix protein osteopontin are associated with the use of ADM as a silicone wrapping. In mice with osteopontin knocked out, FBR attenuation by ADM-coated implants was abrogated. In wild-type mice, the sustained release of recombinant osteopontin from a hydrogel placed adjacent to a silicone implant attenuated the FBR in the absence of ADM. Our findings suggest strategies for the further minimization of the FBR.</p>

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Osteopontin attenuates the foreign-body response to silicone implants

  • 期刊论文

  • 发表日期：

    2025年3月24日

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  • Michelle F. Griffin,
  • Jennifer B. Parker,
  • Ruth Tevlin,
  • Norah E. Liang,
  • Caleb Valencia,
  • Annah Morgan,
  • Maxwell Kuhnert,
  • Mauricio Downer Jr.,
  • Emily L. Meany,
  • Jason L. Guo,
  • Dominic Henn,
  • Renato S. Navarro,
  • Kerry Shefren,
  • Dung Nguyen,
  • Geoffrey C. Gurtner,
  • Sarah C. Heilshorn,
  • Charles K. F. Chan,
  • Michael Januszyk,
  • Eric A. Appel,
  • Arash Momeni,
  • Derrick C. Wan,
  • Michael T. Longaker

摘要

The inflammatory process resulting in the fibrotic encapsulation of implants has been well studied. However, how acellular dermal matrix (ADM) used in breast reconstruction elicits an attenuated foreign-body response (FBR) remains unclear. Here, by leveraging single-cell RNA-sequencing and proteomic data from pairs of fibrotically encapsulated specimens (bare silicone and silicone wrapped with ADM) collected from individuals undergoing breast reconstruction, we show that high levels of the extracellular-matrix protein osteopontin are associated with the use of ADM as a silicone wrapping. In mice with osteopontin knocked out, FBR attenuation by ADM-coated implants was abrogated. In wild-type mice, the sustained release of recombinant osteopontin from a hydrogel placed adjacent to a silicone implant attenuated the FBR in the absence of ADM. Our findings suggest strategies for the further minimization of the FBR.