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<p>Maternal antibodies are essential for protecting fetuses and infants with immature immune systems, and maternal vaccination is a promising strategy to prevent neonatal infections. We previously reported the vaccine efficacy of RBD–PspA, a fusion protein combining the receptor-binding domain of parvovirus B19 (B19V) and pneumococcal surface protein A (PspA). Here, we evaluated the protective efficacy of RBD–PspA-induced maternal immunity and its impact on offspring adaptive immunity development. Offspring of vaccinated mothers exhibited anti-RBD and anti-PspA IgG levels comparable to those of their mothers, with neutralizing activity against B19V. These offspring exhibited significantly improved survival following primary challenge with a pneumococcal strain harboring the same PspA family protein. Surviving offspring demonstrated enhanced survival upon re-challenge with a strain of the same capsule-defined serotype but expressing a different PspA family protein. These findings suggest that maternal pneumococcal vaccination protects offspring and permits the development of protective immunity in pups.</p>

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Maternal PspA antibodies protect neonates and enable serotype-specific immunity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月24日

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  • Takafumi Noguchi,
  • Hidehiko Suzuki,
  • Yuka Koizumi,
  • Mayuko Yamawaki,
  • Takeshi Sugimoto,
  • Paola Miyazato,
  • Yukihiro Akeda,
  • Eiji Morita,
  • Hirotaka Ebina

摘要

Maternal antibodies are essential for protecting fetuses and infants with immature immune systems, and maternal vaccination is a promising strategy to prevent neonatal infections. We previously reported the vaccine efficacy of RBD–PspA, a fusion protein combining the receptor-binding domain of parvovirus B19 (B19V) and pneumococcal surface protein A (PspA). Here, we evaluated the protective efficacy of RBD–PspA-induced maternal immunity and its impact on offspring adaptive immunity development. Offspring of vaccinated mothers exhibited anti-RBD and anti-PspA IgG levels comparable to those of their mothers, with neutralizing activity against B19V. These offspring exhibited significantly improved survival following primary challenge with a pneumococcal strain harboring the same PspA family protein. Surviving offspring demonstrated enhanced survival upon re-challenge with a strain of the same capsule-defined serotype but expressing a different PspA family protein. These findings suggest that maternal pneumococcal vaccination protects offspring and permits the development of protective immunity in pups.