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<p>Therapeutic cancer vaccine efficacy depends on both immune priming and biological context. Although vaccines can generate clinically meaningful antigen-specific T-cell responses, epigenetic repression, microbiome dysbiosis, baseline tumor PD-L1 expression, and immunosuppressive myeloid populations may limit their effectiveness. This review examines how epigenetic and microbiome modulation can enhance antigen visibility, immune durability, and therapeutic responsiveness, using cervical cancer as a clinically relevant model.</p><p></p>

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Epigenetic and microbiome modulation as catalysts for next-generation cancer vaccines

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月27日

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  • Shishir Singh,
  • Aesha Singh,
  • Monisha Banerjee,
  • Atar Singh Kushwah

摘要

Therapeutic cancer vaccine efficacy depends on both immune priming and biological context. Although vaccines can generate clinically meaningful antigen-specific T-cell responses, epigenetic repression, microbiome dysbiosis, baseline tumor PD-L1 expression, and immunosuppressive myeloid populations may limit their effectiveness. This review examines how epigenetic and microbiome modulation can enhance antigen visibility, immune durability, and therapeutic responsiveness, using cervical cancer as a clinically relevant model.