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<p>BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8<sup>+</sup> T cell-dependent protection. Our findings suggest co-immunisation with BCG and adenoviral vector as a promising strategy to combat both TB and malaria in double-endemic regions.</p>

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BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月24日

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  • Sören Reinke,
  • Marta Ulaszewska,
  • Qi Su,
  • Lee Sims,
  • Romain Guyon,
  • Adam Truby,
  • Gundra Raissar,
  • Jelena S. Bezbradica,
  • Joannah R. Fergusson,
  • Anita Milicic

摘要

BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8+ T cell-dependent protection. Our findings suggest co-immunisation with BCG and adenoviral vector as a promising strategy to combat both TB and malaria in double-endemic regions.