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<p>Although individuals with Down syndrome (DS) remain highly vulnerable to severe infections, vaccination remains underutilized. Here we review, specific to people with DS, the safety and efficacy of vaccination, drivers of susceptibility to infection, and existing and emerging opportunities to improve vaccine response. We find that vaccines are generally safe and immunogenic in individuals with DS, although continued research is essential to improve vaccine efficacy and health outcomes.</p>

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Vaccination in individuals with Down syndrome: immune vulnerability, safety, efficacy and opportunities

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月19日

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  • Bernard Khor,
  • Noemi A. Spinazzi,
  • Lina R. Patel,
  • Erika Chelales,
  • Nicole Baumer,
  • Peter Bulova,
  • Brian Chicoine,
  • Arturo Borzutzky,
  • Hana M. El Sahly,
  • Joaquin M. Espinosa,
  • Melissa D. Gans,
  • Andrew A. McCormick,
  • Rebecca Partridge,
  • Eric Rubenstein,
  • Jonathan D. Santoro,
  • Cate Speake,
  • Juanita Valdes Camacho,
  • Kishore Vellody

摘要

Although individuals with Down syndrome (DS) remain highly vulnerable to severe infections, vaccination remains underutilized. Here we review, specific to people with DS, the safety and efficacy of vaccination, drivers of susceptibility to infection, and existing and emerging opportunities to improve vaccine response. We find that vaccines are generally safe and immunogenic in individuals with DS, although continued research is essential to improve vaccine efficacy and health outcomes.