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<p><i>Mycobacterium tuberculosis</i> (Mtb) continues to kill more individuals each year than any other individual pathogen. Advances in bacteriology and immunology signify that Mtb vaccines need to induce responses from multiple components of the immune system, over and above Th1 responses targeted by most current vaccine candidates. This review provides an update on key features of Mtb bacteriology, host immunity, and discusses how new information is driving novel vaccine designs.</p>

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Mycobacterium tuberculosis bacteriology and immunity necessitate a multi-pronged immune strategy for vaccination

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月4日

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  • Jan T. Poolman

摘要

Mycobacterium tuberculosis (Mtb) continues to kill more individuals each year than any other individual pathogen. Advances in bacteriology and immunology signify that Mtb vaccines need to induce responses from multiple components of the immune system, over and above Th1 responses targeted by most current vaccine candidates. This review provides an update on key features of Mtb bacteriology, host immunity, and discusses how new information is driving novel vaccine designs.