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<p>Tick-borne pathogens (TBPs) are expanding globally, with their impact on public health expected to rise due to climate change. Immunizing livestock offers a cost-effective alternative or adjunct to human vaccination. We evaluated two DNA vaccines, one targeting Crimean-Congo hemorrhagic fever virus (CCHFV) and another targeting <i>Hyalomma</i> tick infestation. The <i>Hyalomma</i>-targeting vaccine was designed to disrupt tick feeding by targeting midgut proteins essential for blood digestion and survival; however, its direct role in preventing CCHFV transmission remains unconfirmed. Here, we demonstrate that two doses of the CCHFV vaccine significantly reduced the risk of CCHFV infection in naturally exposed sheep. We further investigated whether the <i>Hyalomma</i> vaccine provided cross-protection against Wad Medani virus (WMV) and <i>Rickettsia conorii</i>, two TBPs endemic to Senegal. Sheep were vaccinated intramuscularly with two doses of DNA vaccine, followed by electroporation, and monitored under natural farming conditions in an endemic region of Senegal. Natural infection with CCHFV, WMV, and <i>R. conorii</i> was assessed longitudinally using pathogen-specific IgG seroconversion as the primary endpoint. The <i>Hyalomma</i> vaccine reduced WMV acquisition, whereas its effect on <i>R. conorii</i> was less pronounced. These findings underscore the potential of veterinary vaccines to mitigate multiple TBPs and reinforce their established role in reducing tick-borne diseases.</p>

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Field vaccination against CCHFV and Hyalomma tick infestation reduces multiple tick-borne infections in sheep

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月16日

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  • Moufid Mhamadi,
  • George Giorgi Babuadze,
  • Aminata Badji,
  • Jose Echanove,
  • Alioune Gaye,
  • El Hadji Ndiaye,
  • Oumar Ndiaye,
  • Mignane Ndiaye,
  • Idrissa Dieng,
  • Ara XIII,
  • Moundhir Mhamadi,
  • Cheikh Talibouya Touré,
  • Mathioro Fall,
  • Ousmane Faye,
  • Hugues Fausther-Bovendo,
  • Oumar Faye,
  • Amadou Alpha Sall,
  • Gary Kobinger

摘要

Tick-borne pathogens (TBPs) are expanding globally, with their impact on public health expected to rise due to climate change. Immunizing livestock offers a cost-effective alternative or adjunct to human vaccination. We evaluated two DNA vaccines, one targeting Crimean-Congo hemorrhagic fever virus (CCHFV) and another targeting Hyalomma tick infestation. The Hyalomma-targeting vaccine was designed to disrupt tick feeding by targeting midgut proteins essential for blood digestion and survival; however, its direct role in preventing CCHFV transmission remains unconfirmed. Here, we demonstrate that two doses of the CCHFV vaccine significantly reduced the risk of CCHFV infection in naturally exposed sheep. We further investigated whether the Hyalomma vaccine provided cross-protection against Wad Medani virus (WMV) and Rickettsia conorii, two TBPs endemic to Senegal. Sheep were vaccinated intramuscularly with two doses of DNA vaccine, followed by electroporation, and monitored under natural farming conditions in an endemic region of Senegal. Natural infection with CCHFV, WMV, and R. conorii was assessed longitudinally using pathogen-specific IgG seroconversion as the primary endpoint. The Hyalomma vaccine reduced WMV acquisition, whereas its effect on R. conorii was less pronounced. These findings underscore the potential of veterinary vaccines to mitigate multiple TBPs and reinforce their established role in reducing tick-borne diseases.