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<p>Controlled human malaria infections after immunization <i>via</i> mosquito bites with radiation attenuated <i>Plasmodium falciparum</i> sporozoites are necessary tools to decipher immune signatures of malaria protection. The phenotype of circulating mononuclear innate cells and the PBMC response to in vitro stimulation unraveled correlates of protection from baseline immune response to sporozoite stimulation (IFN-ƴ secretion and HLA-DR<sup>high</sup> expression) to vaccine-induced immune factors (IL-4 secretion and CD57<sup>-</sup> γδ T cell frequency).</p>

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IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Tanisha M. Robinson,
  • Jessica S. Bolton,
  • Elisabeth H. Duncan,
  • Elke S. Bergmann-Leitner,
  • Marie Mura

摘要

Controlled human malaria infections after immunization via mosquito bites with radiation attenuated Plasmodium falciparum sporozoites are necessary tools to decipher immune signatures of malaria protection. The phenotype of circulating mononuclear innate cells and the PBMC response to in vitro stimulation unraveled correlates of protection from baseline immune response to sporozoite stimulation (IFN-ƴ secretion and HLA-DRhigh expression) to vaccine-induced immune factors (IL-4 secretion and CD57- γδ T cell frequency).