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<p>Although antibodies often exert their effects within the interstitium, the distribution of antibodies within extravascular tissue compartments is not typically measured. Here, IgG titers in peripheral blood and dermal interstitial fluid (ISF) were compared after intramuscular and intradermal immunization with virus-like particle (VLP)-based vaccines. Antibody titers and durability in serum and ISF were similar, indicating that VLP-based vaccines can efficiently elicit strong antibody responses in the skin.</p>

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Immunization with VLP-based vaccines induces high IgG antibody titers in dermal interstitial fluid

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月16日

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  • Alexandra Francian,
  • Srinivasa R. Gadam,
  • Aidan Leyba,
  • Robert M. Taylor,
  • Pavan Muttil,
  • Justin T. Baca,
  • Bryce Chackerian

摘要

Although antibodies often exert their effects within the interstitium, the distribution of antibodies within extravascular tissue compartments is not typically measured. Here, IgG titers in peripheral blood and dermal interstitial fluid (ISF) were compared after intramuscular and intradermal immunization with virus-like particle (VLP)-based vaccines. Antibody titers and durability in serum and ISF were similar, indicating that VLP-based vaccines can efficiently elicit strong antibody responses in the skin.