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<p>Genetically attenuated parasites (GAPs) that arrest during liver stage development have shown significant potential as malaria vaccines. Compared to <i>Plasmodium falciparum</i> GAPs that arrest after 24–48 h (early-arresters), parasites arresting after 6–7 days (late-arresters) have shown superior efficacy, highlighting the importance of liver stage immunity in promoting sterile protection. Here, we describe GAPs tested in humans and the pre-clinical research that led to their creation. We discuss safety and efficacy of existing GAPs with particular focus on their large-scale implementation as malaria vaccines.</p>

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The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月8日

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  • O.A.C. Lamers,
  • B.M.D. Franke-Fayard,
  • M. Roestenberg,
  • J.M.M. Krol

摘要

Genetically attenuated parasites (GAPs) that arrest during liver stage development have shown significant potential as malaria vaccines. Compared to Plasmodium falciparum GAPs that arrest after 24–48 h (early-arresters), parasites arresting after 6–7 days (late-arresters) have shown superior efficacy, highlighting the importance of liver stage immunity in promoting sterile protection. Here, we describe GAPs tested in humans and the pre-clinical research that led to their creation. We discuss safety and efficacy of existing GAPs with particular focus on their large-scale implementation as malaria vaccines.