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<p>Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational design enable precise genetic modifications to enhance safety and immunogenicity. This review highlights key molecular strategies advancing next-generation LAIV development and their potential to accelerate the production of safer, more effective vaccines against seasonal and pandemic influenza.</p>

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Synthetic biology-inspired development of live attenuated influenza vaccines

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月27日

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  • Qisi Zhang,
  • Jiahui Cheng,
  • Jihuan Hou,
  • Yinlei Su,
  • Le Li,
  • Le Tong,
  • Jing Li,
  • Quan Shen,
  • Zihao Wang,
  • Minqi Wu,
  • Zhen Li,
  • Qikai Wang,
  • Yunfei Zhang,
  • Rui Sun,
  • Longlong Si

摘要

Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational design enable precise genetic modifications to enhance safety and immunogenicity. This review highlights key molecular strategies advancing next-generation LAIV development and their potential to accelerate the production of safer, more effective vaccines against seasonal and pandemic influenza.