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<p><i>Haemonchus contortus</i> is a highly pathogenic nematode in small ruminants, causing major production losses and animal welfare concerns. With increasing anthelmintic resistance, vaccination offers a more sustainable control strategy. This study evaluated a novel glycoengineered vaccine produced in Hi5 insect cells in a randomized, controlled trial including Jura × Lacaune sheep. Animals received either Barbervax<sup>®</sup> (BVAX), the glycoengineered vaccine (GEA) composed of five antigens (H11, H11-1, H11-2, H11-4 and GA1), its non-glycoengineered counterpart (NEA), or served as controls. Over 16 weeks, clinical, immunological, and parasitological data were collected. GEA reduced fecal egg counts by 81.09% and worm burden by 25.36%, showing a lower degree of anemia compared to NEA and control. All vaccinated groups exhibited elevated IgG/IgE responses. The results underscore the importance of glycoengineering in achieving protective immunity against <i>H. contortus</i>, supporting the development of highly effective recombinant vaccines against this and other parasitic worms in the future.</p>

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Safety and efficacy of a novel glycoengineered recombinant vaccine candidate against Haemonchus contortus in sheep

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月11日

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  • Floriana Sajovitz-Grohmann,
  • Isabella Adduci,
  • Dirk Werling,
  • Sandra Wiedermann,
  • Licha N. Wortha,
  • Bojan Prole,
  • Julia Zlöbl,
  • Jolina Elster,
  • Alexander Tichy,
  • Anja Joachim,
  • Thomas Wittek,
  • Barbara Hinney,
  • Shi Yan,
  • Katharina Lichtmannsperger

摘要

Haemonchus contortus is a highly pathogenic nematode in small ruminants, causing major production losses and animal welfare concerns. With increasing anthelmintic resistance, vaccination offers a more sustainable control strategy. This study evaluated a novel glycoengineered vaccine produced in Hi5 insect cells in a randomized, controlled trial including Jura × Lacaune sheep. Animals received either Barbervax® (BVAX), the glycoengineered vaccine (GEA) composed of five antigens (H11, H11-1, H11-2, H11-4 and GA1), its non-glycoengineered counterpart (NEA), or served as controls. Over 16 weeks, clinical, immunological, and parasitological data were collected. GEA reduced fecal egg counts by 81.09% and worm burden by 25.36%, showing a lower degree of anemia compared to NEA and control. All vaccinated groups exhibited elevated IgG/IgE responses. The results underscore the importance of glycoengineering in achieving protective immunity against H. contortus, supporting the development of highly effective recombinant vaccines against this and other parasitic worms in the future.