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<p>The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.</p>

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Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月19日

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  • Nir Paran,
  • Christoph Wirblich,
  • Catherine Olal,
  • Alessandro Tarquinio,
  • Kimberly H. Lohmeyer,
  • Drishya Kurup,
  • Stacey Schultz-Cherry,
  • Ismaila Shittu,
  • Gregory C. Gray,
  • Dennis A. Bente,
  • Pia U. Olafson,
  • Matthias J. Schnell

摘要

The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.