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<p>System serology offers a comprehensive approach to evaluate the humoral immune response by evaluating multiple parameters. In the present study, based on four groups of individuals with a different history of SARS-CoV-2 immunization, we analyzed the serum of 180 individuals based on six serological methods to better decipher their immunity. Through our analysis, against different SARS-CoV-2 antigens or variants, we report the importance of system serology to better decipher population immunity. Fc-dependent parameters are key factors underlying the variability of humoral immune response triggered by different schemes of SARS-CoV-2 immunization. With an evolving exposure to new variants, the acquisition of robust cross-reactive Fc-dependent effector functions are likely to be key to control viral replication when neutralizing antibodies are poorly cross-reactive. As booster vaccination remains a useful tool in periodically bolstering humoral immunity, particularly in vulnerable populations, studies should continue to evaluate the humoral immune response using system serology approach.</p>

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Diversity of immunization strongly impacts SARS-CoV-2 antibody function surrogates

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月29日

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  • Benoît Levast,
  • Jérémie Becker,
  • Carla Saade,
  • Inès VuDuc,
  • Kendra Reynaud,
  • Camilo Broc,
  • Charlotte Mignon,
  • Natacha Mariano,
  • Stéphanie Donnat,
  • Shin-Yi Yu,
  • Adrien Saliou,
  • Viet-Dung Tran,
  • Oxana Vratskikh,
  • Céline Couturier,
  • Stéphanie Geoffroy,
  • Anely Tranchot,
  • Christophe Vedrine,
  • Tom Perisse,
  • Lily Bruyere,
  • Martin Killian,
  • Bruno Pozzetto,
  • Dulce Alfaiate,
  • Antonin Bal,
  • Constance d’Aubarede,
  • Vanessa Escuret,
  • Jean-Baptiste Fassier,
  • Nicolas Guibert,
  • Amélie Massardier-Pilonchéry,
  • Mary-Anne Trabaud,
  • Philippe Vanhems,
  • Mitra Saadatian-Elahi,
  • Laetitia Henaff,
  • Karen Louis,
  • Laurent Beloeil,
  • Cyril Guyard,
  • Stéphane Paul,
  • Arnaud Marchant,
  • Sophie Trouillet-Assant

摘要

System serology offers a comprehensive approach to evaluate the humoral immune response by evaluating multiple parameters. In the present study, based on four groups of individuals with a different history of SARS-CoV-2 immunization, we analyzed the serum of 180 individuals based on six serological methods to better decipher their immunity. Through our analysis, against different SARS-CoV-2 antigens or variants, we report the importance of system serology to better decipher population immunity. Fc-dependent parameters are key factors underlying the variability of humoral immune response triggered by different schemes of SARS-CoV-2 immunization. With an evolving exposure to new variants, the acquisition of robust cross-reactive Fc-dependent effector functions are likely to be key to control viral replication when neutralizing antibodies are poorly cross-reactive. As booster vaccination remains a useful tool in periodically bolstering humoral immunity, particularly in vulnerable populations, studies should continue to evaluate the humoral immune response using system serology approach.