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<p>This exploratory study evaluated the neutralization breadth and potential antibody-dependent enhancement (ADE) risk following a single-dose of the KD-382 live-attenuated tetravalent dengue vaccine over 12 months in flavivirus-naïve healthy adults. Using single-round infectious particles representing 17 dengue virus genotypes, KD-382-induced antibodies demonstrated durable cross-genotype neutralizing activity, with minimal in vitro ADE risk. These findings highlight KD-382’s potential for broad protection and underscore the importance of long-term monitoring in dengue-naïve populations.</p>

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Cross-genotype immunogenicity and antibody-dependent enhancement of KD-382 dengue vaccine in flavivirus-naïve adults

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月9日

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  • Jean Claude Balingit,
  • Motoharu Abe,
  • Ryosuke Suzuki,
  • Dalouny Xayavong,
  • Mya Myat Ngwe Tun,
  • Yuki Takamatsu,
  • Kengo Sonoda,
  • Kouichi Morita

摘要

This exploratory study evaluated the neutralization breadth and potential antibody-dependent enhancement (ADE) risk following a single-dose of the KD-382 live-attenuated tetravalent dengue vaccine over 12 months in flavivirus-naïve healthy adults. Using single-round infectious particles representing 17 dengue virus genotypes, KD-382-induced antibodies demonstrated durable cross-genotype neutralizing activity, with minimal in vitro ADE risk. These findings highlight KD-382’s potential for broad protection and underscore the importance of long-term monitoring in dengue-naïve populations.