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<p>We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.</p>

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Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月13日

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  • Guy de Bruyn,
  • Haritha Adhikarla,
  • Caroline K. Brackett,
  • Yichen Jia,
  • Premkumar Lakshmanane,
  • Sarah V. Mudrak,
  • Sheetal Sawant,
  • Donghui Zhang,
  • Roman M. Chicz,
  • Saranya Sridhar,
  • Georgia D. Tomaras,
  • Kelly E. Seaton

摘要

We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.