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<p>We report a comprehensive evaluation of the toxin B (TcdB) vaccine adjuvanted with a dual Toll-like receptor ligand liposome adjuvant for <i>Clostridioides difficile</i> infection (CDI). The vaccine completely protected mice from a lethal infection. Compared to alum adjuvanted TcdB, it generated functionally superior systemic antibodies and supported strong memory B cell and gut IgA responses. This pharmaceutically acceptable adjuvant platform holds promise for developing a next-generation CDI vaccine.</p>

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Enhanced immunogenicity of a Clostridioides difficile TcdB vaccine adjuvanted with a synthetic dual-TLR ligand adjuvant

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月18日

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  • Farha Naz,
  • Nicholas Hagspiel,
  • Feifan Xu,
  • Brandon Thompson,
  • G. Brett Moreau,
  • Mary Young,
  • Joel Herbein,
  • Christopher B. Fox,
  • William A. Petri,
  • Mayuresh M. Abhyankar

摘要

We report a comprehensive evaluation of the toxin B (TcdB) vaccine adjuvanted with a dual Toll-like receptor ligand liposome adjuvant for Clostridioides difficile infection (CDI). The vaccine completely protected mice from a lethal infection. Compared to alum adjuvanted TcdB, it generated functionally superior systemic antibodies and supported strong memory B cell and gut IgA responses. This pharmaceutically acceptable adjuvant platform holds promise for developing a next-generation CDI vaccine.